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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Tel: +1 (206) 374-1102
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CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
CYP8B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless.
| Gene Name: | cytochrome P450, family 8, subfamily B, polypeptide 1 |
| Family/Subfamily: | Cytochrome P450 , not assigned-Cytochrome P450 |
| Synonyms: | CYP8B1, CYP12, Cytochrome P450 8B1, CP8B, Sterol 12-alpha-hydroxylase, Sterol 12alpha-hydroxylase, CYPVIIIB1 |
| Target Sequences: | NM_004391 NP_004382.2 Q9UNU6 |
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