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CYP8B1

cytochrome P450, family 8, subfamily B, polypeptide 1

CYP8B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless.

Gene Name: cytochrome P450, family 8, subfamily B, polypeptide 1
Family/Subfamily: Cytochrome P450 , not assigned-Cytochrome P450
Synonyms: CYP8B1, CYP12, Cytochrome P450 8B1, CP8B, Sterol 12-alpha-hydroxylase, Sterol 12alpha-hydroxylase, CYPVIIIB1
Target Sequences: NM_004391 NP_004382.2 Q9UNU6

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Products
Antibodies (18)
Primary (18)
CYP8B1 (18)
Human (18)
Mouse (9)
Rat (4)
Chimpanzee (3)
IHC (7)
IHC-P (3)
WB (15)
Flo (1)
ELISA (3)
IF (1)
Peptide-ELISA (2)
rabbit (18)
Product Group
IHCPlus (1)
IgG (9)
polyclonal pc (18)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
Unconjugated (12)
aa219-268 (4)
Internal (2)
340-420 aa, Internal (1)
aa357-406 (1)
aa416-461 (1)
aa471-501 (1)
No (18)
CYP8B1 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CYP8B1 Rabbit anti-Human Polyclonal (aa357-406) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
CYP8B1 Antibody - Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with CYP8B1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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CYP8B1 Rabbit anti-Human Polyclonal (aa471-501) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
CYP8B1 Antibody - Immunohistochemistry image at a dilution of 1:300 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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CYP8B1 Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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CYP8B1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
CYP8B1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
CYP8B1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
FITC Conjugated
50 µg/$294; 100 µg/$360
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CYP8B1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µl/$334; 100 µl/$397
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CYP8B1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
CYP8B1 Antibody - Western blot of CYP8B1 antibody
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CYP8B1 Rabbit anti-Human Polyclonal (340-420 aa, Internal) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CYP8B1 Antibody - 1:100 staining mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CYP8B1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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CYP8B1 Rabbit anti-Human Polyclonal (aa416-461) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
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CYP8B1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
CYP8B1 Antibody - CYP8B1 antibody Western blot of HepG2 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYP8B1 Rabbit anti-Human Polyclonal (aa219-268) Antibody
Human
WB
Unconjugated
100 µl/$424
CYP8B1 Antibody - CYP8B1 antibody Western blot of HepG2 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYP8B1 Rabbit anti-Human Polyclonal (aa219-268) (HRP) Antibody
Human, Chimpanzee
WB
HRP Conjugated
100 µl/$469
CYP8B1 Antibody - CYP8B1 antibody Western blot of HepG2 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYP8B1 Rabbit anti-Human Polyclonal (aa219-268) (Biotin) Antibody
Human, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
CYP8B1 Antibody - CYP8B1 antibody Western blot of HepG2 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYP8B1 Rabbit anti-Human Polyclonal (aa219-268) (FITC) Antibody
Human, Chimpanzee
WB
FITC Conjugated
100 µl/$469
CYP8B1 Antibody - Western blot analysis of Cytochrome P450 8B1 expression in K562 (A); SP2/0 (B); PC12 (C) whole cell lysates.
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CYP8B1 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
CYP8B1 Antibody - Western blot analysis of Cytochrome P450 8B1 expression in HEK293T (A); Raw264.7 (B); H9C2 (C) whole cell lysates.
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CYP8B1 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
Viewing 1-18 of 18 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).