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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:24138531). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids, such as 3-hydroxypalmitate, 3-hydroxyoleate, 3-hydroxyarachidonate, and 3-hydroxystearate (PubMed:18065749, PubMed:19932081). Oxidizes drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine and imipramine (PubMed:15364545).
| Gene Name: | cytochrome P450, family 4, subfamily F, polypeptide 11 |
| Family/Subfamily: | Cytochrome P450 , not assigned-Cytochrome P450 |
| Synonyms: | CYP4F11, CYPIVF11, Cytochrome P450 4F11 |
| Target Sequences: | NM_021187 NP_067010.3 Q9HBI6 |
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