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CYP46A1 / CYP46
cytochrome P450, family 46, subfamily A, polypeptide 1
CYP46A1 / CYP46 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
| Gene Name: | cytochrome P450, family 46, subfamily A, polypeptide 1 |
| Family/Subfamily: | Cytochrome P450 , not assigned-Cytochrome P450 |
| Synonyms: | CYP46A1, Cytochrome P450 46A1, Cholesterol 24-hydroxylase, CH24H, CP46, CYP46 |
| Target Sequences: | NM_006668 NP_006659.1 Q9Y6A2 |
Publications (1)
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