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CYP46A1 / CYP46

cytochrome P450, family 46, subfamily A, polypeptide 1

CYP46A1 / CYP46 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.

Gene Name: cytochrome P450, family 46, subfamily A, polypeptide 1
Family/Subfamily: Cytochrome P450 , not assigned-Cytochrome P450
Synonyms: CYP46A1, Cytochrome P450 46A1, Cholesterol 24-hydroxylase, CH24H, CP46, CYP46
Target Sequences: NM_006668 NP_006659.1 Q9Y6A2

Publications (1)

1
Differential expression of cholesterol hydroxylases in Alzheimer's disease. Brown J, Theisler C, Silberman S, Magnuson D, Gottardi-Littell N, Lee JM, Yager D, Crowley J, Sambamurti K, Rahman MM, Reiss AB, Eckman CB, Wolozin B. The Journal of biological chemistry. 2004 279:34674-81. (WB; Rabbit, Human) [PubMed:15148325]

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Products
Antibodies (24)
Primary (24)
CYP46A1 / CYP46 (24)
Human (24)
Mouse (7)
Rat (5)
Bat (3)
Bovine (3)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Guinea pig (3)
Hamster (3)
Horse (3)
Monkey (4)
Pig (3)
Xenopus (3)
IHC (3)
IHC-P (1)
WB (23)
ELISA (8)
ICC (1)
Peptide-ELISA (1)
rabbit (17)
mouse (7)
Product Group
IHCPlus (1)
IgG (16)
IgG1,k (6)
monoclonal mc (7)
polyclonal pc (17)
APC Conjugated (2)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (2)
Unconjugated (11)
aa396-445 (4)
aa201-300 (2)
No (24)
CYP46A1 / CYP46 Antibody - Anti-CYP46A1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.
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CYP46A1 / CYP46 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
CYP46A1 / CYP46 Antibody - Immunohistochemistry of paraffin-embedded human prostate.
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CYP46A1 / CYP46 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CYP46A1 / CYP46 Antibody - HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYP46A1 / CYP46 Rabbit anti-Human Polyclonal (aa396-445) Antibody
Human
WB
Unconjugated
100 µl/$424
CYP46A1 / CYP46 Antibody - HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYP46A1 / CYP46 Rabbit anti-Human Polyclonal (aa396-445) (HRP) Antibody
Xenopus, Bat, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Horse, Chimpanzee, Human, Monkey, Gibbon
WB
HRP Conjugated
100 µl/$469
CYP46A1 / CYP46 Antibody - HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYP46A1 / CYP46 Rabbit anti-Human Polyclonal (aa396-445) (Biotin) Antibody
Xenopus, Bat, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Horse, Chimpanzee, Human, Monkey, Gibbon
WB
Biotin Conjugated
100 µl/$469
CYP46A1 / CYP46 Antibody - HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYP46A1 / CYP46 Rabbit anti-Human Polyclonal (aa396-445) (FITC) Antibody
Xenopus, Bat, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Horse, Chimpanzee, Human, Monkey, Gibbon
WB
FITC Conjugated
100 µl/$469
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CYP46A1 / CYP46 Mouse anti-Human Monoclonal (aa201-300) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$705
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CYP46A1 / CYP46 Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$904
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CYP46A1 / CYP46 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
100 µl/$904
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CYP46A1 / CYP46 Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
100 µl/$904
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CYP46A1 / CYP46 Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, WB
PE Conjugated
100 µl/$904
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CYP46A1 / CYP46 Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, WB
APC Conjugated
100 µl/$904
CYP46A1 / CYP46 Antibody - Sample (30 ug of whole cell lysate) A: MCF-7 7.5% SDS PAGE CYP46A1 antibody diluted at 1:1000
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CYP46A1 / CYP46 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$450
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CYP46A1 / CYP46 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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CYP46A1 / CYP46 Mouse anti-Human Monoclonal (aa201-300) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$680
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CYP46A1 / CYP46 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
CYP46A1 / CYP46 Antibody - Western blot analysis of Cytochrome P450 46A1 using HuvEc whole cells lysates
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CYP46A1 / CYP46 Rabbit anti-Human Polyclonal Antibody
Mouse, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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CYP46A1 / CYP46 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
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CYP46A1 / CYP46 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$937
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CYP46A1 / CYP46 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$937
Select
CYP46A1 / CYP46 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$937
Select
CYP46A1 / CYP46 Rabbit anti-Human Polyclonal (PE) Antibody
Human
WB
PE Conjugated
100 µl/$937
Select
CYP46A1 / CYP46 Rabbit anti-Human Polyclonal (APC) Antibody
Human
WB
APC Conjugated
100 µl/$937
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CYP46A1 / CYP46 Rabbit anti-Human Polyclonal Antibody
Human
Unconjugated
100 µg/$331
Viewing 1-24 of 24 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).