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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Fax: +1 (206) 577-4565
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CYP2C9 / Cytochrome P450 2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2C9 / Cytochrome P450 2C9 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
| Gene Name: | cytochrome P450, family 2, subfamily C, polypeptide 9 |
| Family/Subfamily: | Cytochrome P450 , not assigned-Cytochrome P450 |
| Synonyms: | CYP2C9, Cytochrome P450 PB-1, Cytochrome P-450MP, CYP2C10, CYPIIC9, Cytochrome P450 2C9, Cytochrome P450 MP-4, Cytochrome P450 MP-8, p450IIC9, S-mephenytoin 4-hydroxylase, CPC9, CYP2C |
| Target Sequences: | NM_000771 NP_000762.2 P11712 |
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