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CYP26B1

cytochrome P450, family 26, subfamily B, polypeptide 1

Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.

Gene Name: cytochrome P450, family 26, subfamily B, polypeptide 1
Synonyms: CYP26B1, Cytochrome P450RAI-2, Cytochrome P450 26B1, p450RAI2, RHFCA, CYP26A2, Cytochrome P450 26A2, p450RAI-2
Target Sequences: NM_019885 NP_063938.1 Q9NR63

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Products
Antibodies (32)
Primary (32)
CYP26B1 (32)
Human (32)
Mouse (10)
Rat (10)
Bat (3)
Bovine (3)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Guinea pig (3)
Hamster (1)
Horse (4)
Monkey (4)
Pig (3)
Rabbit (4)
Xenopus (3)
IHC (5)
IHC-P (3)
WB (31)
ELISA (9)
IF (2)
IP (1)
Peptide-ELISA (2)
rabbit (23)
mouse (8)
goat (1)
Product Group
IHCPlus (2)
IgG (4)
IgG1 (2)
IgG2a,k (6)
monoclonal mc (8)
polyclonal pc (24)
OTI4A8 (2)
APC (1)
APC Conjugated (2)
Biotin Conjugated (4)
Carrier-free (1)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Unconjugated (14)
aa1-512 (8)
C-Terminus (4)
aa35-84 (4)
aa229-512 (2)
aa131-231 (1)
aa398-430 (1)
aa418-430 (1)
No (32)
CYP26B1 Antibody - Anti-CYP26B1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CYP26B1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
CYP26B1 Antibody - Anti-CYP26B1 antibody IHC of human small intestine, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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CYP26B1 Goat anti-Human Polyclonal (aa418-430) Antibody
Rabbit, Mouse, Rat, Hamster, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
CYP26B1 Antibody - CYP26B1 antibody Western blot of Jurkat lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYP26B1 Rabbit anti-Human Polyclonal (aa35-84) Antibody
Human
WB
Unconjugated
100 µl/$424
CYP26B1 Antibody - CYP26B1 antibody Western blot of Jurkat lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYP26B1 Rabbit anti-Human Polyclonal (aa35-84) (FITC) Antibody
Xenopus, Bat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Chimpanzee, Human, Monkey, Gibbon
WB
FITC Conjugated
100 µl/$469
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CYP26B1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
CYP26B1 Antibody - 1:100 staining human brain carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CYP26B1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CYP26B1 Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with CYP26B1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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CYP26B1 Rabbit anti-Human Polyclonal (aa398-430) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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CYP26B1 Mouse anti-Human Monoclonal (aa131-231) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$705
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CYP26B1 Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$904
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CYP26B1 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
100 µl/$904
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CYP26B1 Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
100 µl/$904
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CYP26B1 Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, WB
APC Conjugated
100 µl/$904
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CYP26B1 Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, WB
PE Conjugated
100 µl/$904
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CYP26B1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
CYP26B1 Antibody - Western Blot (WB) analysis of Mouse Brain cells using Antibody diluted at 1:800.
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CYP26B1 Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CYP26B1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY CYP26B1. (Right lane) cDNA for 48 hrs and lysed
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CYP26B1 Mouse anti-Human Monoclonal (aa229-512) (OTI4A8) Antibody
Human
WB
Unconjugated
100 µl/$434
CYP26B1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY CYP26B1. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CYP26B1. (1:2000)
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CYP26B1 Mouse anti-Human Monoclonal (aa229-512) (Carrier-free) (OTI4A8) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
CYP26B1 Antibody - CYP26B1 antibody Western blot of ACHN lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYP26B1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
CYP26B1 Antibody - Western blot of recombinant CYP26B1.
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CYP26B1 Rabbit anti-Human Polyclonal (aa1-512) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
CYP26B1 Antibody - Western blot of recombinant CYP26B1.
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CYP26B1 Rabbit anti-Human Polyclonal (aa1-512) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593
CYP26B1 Antibody - Western blot of recombinant CYP26B1.
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CYP26B1 Rabbit anti-Human Polyclonal (aa1-512) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
CYP26B1 Antibody - Western blot of recombinant CYP26B1.
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CYP26B1 Rabbit anti-Human Polyclonal (aa1-512) (APC) Antibody
Human
WB
APC Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
CYP26B1 Antibody - Western blot of recombinant CYP26B1.
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CYP26B1 Rabbit anti-Human Polyclonal (aa1-512) (APC, Cy7) Antibody
Human
WB
APC, Cy7 Conjugated
100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676
CYP26B1 Antibody - Western blot of recombinant CYP26B1.
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CYP26B1 Rabbit anti-Human Polyclonal (aa1-512) (PE) Antibody
Human
WB
PE Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
CYP26B1 Antibody - Western blot analysis of extracts of various cell lines, using CYP26B1 antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
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CYP26B1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Viewing 1-25 of 32 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).