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CYP1B1

cytochrome P450, family 1, subfamily B, polypeptide 1

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta-estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression.

Gene Name: cytochrome P450, family 1, subfamily B, polypeptide 1
Family/Subfamily: Cytochrome P450 , not assigned-Cytochrome P450
Synonyms: CYP1B1, Aryl hydrocarbon hydroxylase, CP1B, Cytochrome P450 1B1, CYPIB1, GLC3A, p4501B1
Target Sequences: NM_000104 NP_000095.2 Q16678

Publications (1)

1
Lung Epithelial CYP1 Activity Regulates Aryl Hydrocarbon Receptor Dependent Allergic Airway Inflammation. Francesca Alessandrini, Renske de Jong, Maria Wimmer, Ann-Marie Maier, Isis Fernandez, Miriam Hils, Jeroen T Buters, Tilo Biedermann, Ulrich M Zissler, Christian Hoffmann, Julia Esser-von-Bieren, Carsten B Schmidt-Weber, Caspar Ohnmacht. Frontiers in immunology. 2022 June;13:901194. [Full Text Article] [PubMed:35734174] [PMC:PMC9207268] Related Antibodies: LS-B1790.

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CYP1B1 Protein - Active Cytochrome P450 1B1 (CYP1B1) by SDS-PAGE
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E. coli
His, N-Terminal
18/16kDa
10 µg/$382; 50 µg/$952; 200 µg/$1,612; 100 µg/$1,378; 1 mg/$3,041; 500 µg/$2,437; 5 mg/$6,651; 2 mg/$3,548
CYP1B1 Protein - Recombinant Cytochrome P450 1B1 By SDS-PAGE
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E. coli
His
17.9 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
CYP1B1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CYP1B1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
CYP1B1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
60.7 kDa
20 µg/$150
CYP1B1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
60.7 kDa
100 µg/$494
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).