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CYP19 / Aromatase

cytochrome P450, family 19, subfamily A, polypeptide 1

CYP19 / Aromatase is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants.

Gene Name: cytochrome P450, family 19, subfamily A, polypeptide 1
Family/Subfamily: Cytochrome P450 , not assigned-Cytochrome P450
Synonyms: CYP19A1, ARO1, CYAR, CPV1, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, CYP19, Estrogen synthase, Estrogen synthetase, P-450AROM, ARO, Aromatase
Target Sequences: NM_031226 NP_000094.2 P11511

Publications (8)

1
Systematic determination of differential gene expression in the primate corpus luteum during the luteal phase of the menstrual cycle. Bogan RL, Murphy MJ, Stouffer RL, Hennebold JD. Molecular endocrinology (Baltimore, Md.). 2008 22:1260-73. [PubMed:18258683] [PMC:PMC2366192]
2
Dynamic changes in gene expression that occur during the period of spontaneous functional regression in the rhesus macaque corpus luteum. Bogan RL, Murphy MJ, Hennebold JD. Endocrinology. 2009 150:1521-9. [PubMed:18948396] [PMC:PMC2654732]
3
Aromatase expression in human peripheral blood leucocytes (PBLs) and in various tissues in primates: studies in elderly humans and cynomolgus monkeys. Pignatti E, Casarini L, Scaltriti S, Wistuba J, Schlatt S, Rossi A, Lachhab A, Taliani E, Carani C, Simoni M. Journal of medical primatology. 2012 41:372-83. (WB; Human, Primate) [PubMed:22978812]
4
Androgen metabolites impact CSF amines and axonal serotonin via MAO-A and -B in male macaques. Bethea CL, Phu K, Kim A, Reddy AP. Neuroscience. 2015 301:576-89. (IHC; Macaque) [Full Text Article] [PubMed:26086546] [PMC:PMC4520442] Related Antibodies: LS-B521.
5
Aromatase and neuroinflammation in rat focal brain ischemia. Zhong YH, Dhawan J, Kovoor JA, Sullivan J, Zhang WX, Choi D, Biegon A. The Journal of steroid biochemistry and molecular biology. 2017 174:225-233. (IHC; Rat) [Full Text Article] [PubMed:28964927] Related Antibodies: LS-B3021.
6
Bisphenol S negatively affects the meotic maturation of pig oocytes. Žalmanová T, Hošková K, Nevoral J, Adámková K, Kott T, Šulc M, Kotíková Z, Prokešová Š, Jílek F, Králíčková M, Petr J. Scientific reports. 2017 7:485. (WB; Human) [Full Text Article] [PubMed:28352085] Related Antibodies: LS-C188219.
7
Sex Differences in Estradiol Secretion by Trigeminal Brainstem Neurons. Bereiter DA, Thompson R, Rahman M. Frontiers in integrative neuroscience. 2019 February;13:3. [Full Text Article] [PubMed:30809134] [PMC:PMC6379465]
8
Resveratrol protects the ovary against chromium-toxicity by enhancing endogenous antioxidant enzymes and inhibiting metabolic clearance of estradiol. Sakhila K Banu, Jone A Stanley, Kirthiram K Sivakumar, Joe A Arosh, Robert C Burghardt. Toxicology and applied pharmacology. 2016 July;303:65-78. [Full Text Article] [PubMed:27129868] [PMC:PMC5830085] Related Antibodies: LS-C119485.
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ELISA Kits (19)
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CYP19 / Aromatase (19)
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CYP19 / Aromatase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CYP19 / Aromatase ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CYP19 / Aromatase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$834
CYP19 / Aromatase ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CYP19 / Aromatase ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CYP19 / Aromatase ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CYP19 / Aromatase ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CYP19 / Aromatase ELISA Kit
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Competitive EIA
96-Well Microplate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$1,023
CYP19 / Aromatase ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
18.75 - 1200 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$958
CYP19 / Aromatase ELISA Kit
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Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CYP19 / Aromatase ELISA Kit
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Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$929
CYP19 / Aromatase ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
CYP19 / Aromatase ELISA Kit
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Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$929
CYP19 / Aromatase ELISA Kit
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Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$783
CYP19 / Aromatase ELISA Kit
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Sandwich
96-Well Microplate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
CYP19 / Aromatase ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.125 - 8 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CYP19 / Aromatase ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
CYP19 / Aromatase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CYP19 / Aromatase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$893
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).