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Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Telephone Numbers
Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
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Additional Contact Details
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CYP11B2 / Aldosterone Synthase
cytochrome P450, family 11, subfamily B, polypeptide 2
CYP11B2 / Aldosterone Synthase is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency.
| Gene Name: | cytochrome P450, family 11, subfamily B, polypeptide 2 |
| Family/Subfamily: | Cytochrome P450 , not assigned-Cytochrome P450 |
| Synonyms: | CYP11B2, ALDOS, Aldosterone synthase, CYP11BL, CYPXIB2, Cytochrome P-450Aldo, Cytochrome P-450C18, P-450C18, p450aldo, Steroid 18-hydroxylase, Steroid 11-beta-monooxygenase, CYP11B, p450C18, Steroid 11-beta/18-hydroxylase |
| Target Sequences: | NM_000498 NP_000489.3 P19099 |
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