CYLD

cylindromatosis (turban tumor syndrome)

Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis.

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Products

Proteins (9)

Type

Over-Expression Lysate (4)

Recombinant (5)

Target

CYLD (9)

Publications

No (9)

Tag

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (7)

Species

Human (7)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (5)

Wheat Germ Extract (1)

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CYLD Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119454

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

106.9 kDa

Price:

100 µg/$494

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CYLD Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119495

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

106.9 kDa

Price:

100 µg/$710

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Human CYLD Protein (Recombinant GST, N-terminus) (aa854-953) - LS-G58272

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CYLD Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69074

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

107.1 kDa

Price:

20 µg/$1,107

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Human CYLD Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69075

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

106.9 kDa

Price:

20 µg/$1,107

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Human CYLD Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69076

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

106.9 kDa

Price:

20 µg/$1,107

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Human CYLD Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83792

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

106.9 kDa

Price:

20 µg/$150

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Human CYLD Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83793

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

106.9 kDa

Price:

20 µg/$215

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Human CYLD Protein (Recombinant His-T7) (aa170-338) - LS-G14914

Source:

E. coli

Tag:

His-T7

Molecular Weight:

22.1 kDa

Price:

50 µg/$412; 10 µg/$276; 200 µg/$822; 100 µg/$657; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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