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CYB5R3 / B5R

cytochrome b5 reductase 3

CYB5R3 / B5R is cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias.

Gene Name: cytochrome b5 reductase 3
Synonyms: CYB5R3, B5R, Cytochrome b5 reductase 3, DIA1, Diaphorase-1, Cytochrome b5 reductase, NADH-cytochrome b5 reductase, NADH-cytochrome b5 reductase 3
Target Sequences: NM_007326 NP_015565.1 P00387

Publications (1)

1
Endothelial cell a-globin and its molecular chaperone a-hemoglobin-stabilizing protein regulate arteriolar contractility. Lechauve C, Butcher JT, Freiwan A, Biwer LA, Keith JM, Good ME, Ackerman H, Tillman HS, Kiger L, Isakson BE, Weiss MJ. The Journal of clinical investigation. 2018 November;128:5073-5082. [Full Text Article] [PubMed:30295646] [PMC:PMC6205378]

☰ Filters
Antibodies (35)
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CYB5R3 / B5R (56)
Human (31)
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CYB5R3 / B5R Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
CYB5R3 / B5R Antibody - Western blot of CYB5R3 antibody
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CYB5R3 / B5R Rabbit anti-Human Polyclonal (110-190 aa, Internal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CYB5R3 / B5R Antibody - IHC of paraffin-embedded Human breast tissue using anti-CYB5R3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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CYB5R3 / B5R Mouse anti-Human Monoclonal (OTI1E8) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
CYB5R3 / B5R Antibody - IHC of paraffin-embedded Human breast tissue using anti-CYB5R3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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CYB5R3 / B5R Mouse anti-Human Monoclonal (Carrier-free) (OTI1E8) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CYB5R3 / B5R Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-CYB5R3 mouse monoclonal antibody.
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CYB5R3 / B5R Mouse anti-Human Monoclonal (OTI2A10) Antibody
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
CYB5R3 / B5R Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-CYB5R3 mouse monoclonal antibody.
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CYB5R3 / B5R Mouse anti-Human Monoclonal (Carrier-free) (OTI2A10) Antibody
Dog, Human, Monkey
Flo, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CYB5R3 / B5R Antibody - Anti-CYB5R3 / B5R antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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CYB5R3 / B5R Goat anti-Human Polyclonal (aa317-330) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
CYB5R3 / B5R Antibody - Anti-CYB5R3 / B5R antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYB5R3 / B5R Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CYB5R3 / B5R Antibody - Anti-CYB5R3 / B5R antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYB5R3 / B5R Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
CYB5R3 / B5R Antibody - Anti-CYB5R3 / B5R antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYB5R3 / B5R Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
CYB5R3 / B5R Antibody - Anti-CYB5R3 / B5R antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYB5R3 / B5R Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
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CYB5R3 / B5R Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
CYB5R3 / B5R Antibody - 1:100 staining mouse testis tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CYB5R3 / B5R Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CYB5R3 / B5R Antibody - Immunohistochemistry analysis of paraffin-embedded human placenta tissue, using CYB5R3 Antibody. The picture on the right is blocked with the synthesized peptide.
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CYB5R3 / B5R Rabbit anti-Human Polyclonal (aa137-186) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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CYB5R3 / B5R Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
CYB5R3 / B5R Antibody - Immunohistochemical analysis of CYB5R3 staining in human liver cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CYB5R3 / B5R Rabbit anti-Human Polyclonal (Internal) Antibody
Dog, Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$299
CYB5R3 / B5R Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human placenta tissue using CYB5R3 antibody.
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CYB5R3 / B5R Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
CYB5R3 / B5R Antibody - Human Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CYB5R3 / B5R Goat anti-Mouse Polyclonal (aa284-297) Antibody
Mouse, Rat, Pig
IHC-P, Peptide-ELISA, WB
Unconjugated
100 µg/$503
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CYB5R3 / B5R Rabbit anti-Pig Polyclonal Antibody
Pig
ELISA, ID, IE, WB
Unconjugated
5 mg/$558
CYB5R3 / B5R Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CYB5R3 / B5R Rabbit anti-Human Polyclonal (aa191-240) Antibody
Human
IHC-P, WB
Unconjugated
100 µl/$424
CYB5R3 / B5R Antibody - Western blot analysis of the lysates from K562 cells using CYB5R3 antibody.
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CYB5R3 / B5R Rabbit anti-Human Polyclonal (aa120-169) Antibody
Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CYB5R3 / B5R Antibody - Anti-CYB5R3 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CYB5R3.
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CYB5R3 / B5R Mouse anti-Human Monoclonal (OTI1E3) Antibody
IF, WB
Unconjugated
100 µl/$434
CYB5R3 / B5R Antibody - Anti-CYB5R3 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CYB5R3.
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CYB5R3 / B5R Mouse anti-Human Monoclonal (Carrier-free) (OTI1E3) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CYB5R3 / B5R Antibody - IHC of CYB5R3 (I169) pAb in paraffin-embedded human placenta tissue.
Select
CYB5R3 / B5R Rabbit anti-Human Polyclonal (Ile169) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
Select
CYB5R3 / B5R Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
100 µl/$386
Viewing 1-25 of 56 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).