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CXCR3

chemokine (C-X-C motif) receptor 3

CXCR3 is a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).

Gene Name: chemokine (C-X-C motif) receptor 3
Family/Subfamily: GPCR , Chemokine
Synonyms: CXCR3, C-x-c chemokine receptor 3, CD183 antigen, CKR-L2, CXCR-3, CMKAR3, CD182, CD183, Cxcr3a, GPR9, IP-10 receptor, IP10-R, Mig receptor, MigR, Mig-R, Chemokine (C-X-C) receptor 3, CXC-R3, Cxcr3b, G protein-coupled receptor 9, IP10 receptor
Target Sequences: NM_001504 NP_001495.1 P49682

Publications (5)

1
Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer. Denkert C, Loibl S, Noske A, Roller M, Mller BM, Komor M, Budczies J, Darb-Esfahani S, Kronenwett R, Hanusch C, von Trne C, Weichert W, Engels K, Solbach C, Schrader I, Dietel M, von Minckwitz G. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2010 28:105-13. (IHC-P; Human) [PubMed:19917869] Related Antibodies: LS-C6283.
2
Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints. Mikucki ME, Fisher DT, Matsuzaki J, Skitzki JJ, Gaulin NB, Muhitch JB, Ku AW, Frelinger JG, Odunsi K, Gajewski TF, Luster AD, Evans SS. Nature communications. 2015 6:7458. (Block; Human) [Full Text Article] [PubMed:26109379] [PMC:PMC4605273] Related Antibodies: LS-C6283.
3
CXCR3 regulates CD4+ T cell cardiotropism in pressure overload-induced cardiac dysfunction. Ngwenyama N, Salvador AM, Velázquez F, Nevers T, Levy A, Aronovitz M, Luster AD, Huggins GS, Alcaide P. JCI insight. 2019 April;4:pii: 125527. [Full Text Article] [PubMed:30779709] [PMC:PMC6483643] Related Antibodies: LS-B10183.
4
CXCL10/CXCR3 signaling contributes to an inflammatory microenvironment and its blockade enhances progression of murine pancreatic precancerous lesions. Veethika Pandey, Alicia Fleming-Martinez, Ligia Bastea, Heike R Doeppler, Jillian Eisenhauer, Tam Le, Brandy Edenfield, Peter Storz. eLife. 2021 July;10: [Full Text Article] [PubMed:34328416] [PMC:PMC8360647] Related Antibodies: LS-C332293.
5
Cross-linking of T cell to B cell lymphoma by the T cell bispecific antibody CD20-TCB induces IFN?/CXCL10-dependent peripheral T cell recruitment in humanized murine model. Floriana Cremasco, Elena Menietti, Dario Speziale, Johannes Sam, Stefano Sammicheli, Marine Richard, Ahmet Varol, Christian Klein, Pablo Umana, Marina Bacac, Sara Colombetti, Mario Perro. PloS one. 2021 Jan;16:e0241091. [Full Text Article] [PubMed:33406104] [PMC:PMC7787458] Related Antibodies: LS-B10183.
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).