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CXCR1

chemokine (C-X-C motif) receptor 1

CXCR1 is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.

Gene Name: chemokine (C-X-C motif) receptor 1
Family/Subfamily: GPCR , Chemokine
Synonyms: CXCR1, C-C, Chemokine c-x-c receptor 1, CKR-1, CMKAR1, CD128, CD181, CD181 antigen, CXCR-1, CXC-R1, IL-8R A, Il8 receptor a, Interleukin 8 receptor a, Interleukin 8 receptor alpha, Interleukin 8 receptor, alpha, Interleukin-8 receptor type A, IL8RBA, Interleukin-8 receptor type 1, C-C-CKR-1, CDw128a, IL-8 receptor type 1, IL8R1, IL8RA
Target Sequences: NM_000634 NP_000625.1 P25024

Publications (3)

1
Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human) [Full Text Article] [PubMed:25870011] [PMC:PMC4623112] Related Antibodies: LS-C178869.
2
Inflammatory Bowel Disease Types Differ in Markers of Inflammation, Gut Barrier and in Specific Anti-Bacterial Response. Stepan Coufal, Natalie Galanova, Lukas Bajer, Zuzana Gajdarova, Dagmar Schierova, Zuzana Jiraskova Zakostelska, Klara Kostovcikova, Zuzana Jackova, Zuzana Stehlikova, Pavel Drastich, Helena Tlaskalova-Hogenova, Miloslav Kverka. Cells. 2019 Jul;8:719. [Full Text Article] [PubMed:31337064] [PMC:PMC6678638]
3
ABCB5 maintains melanoma-initiating cells through a proinflammatory cytokine signaling circuit. Wilson BJ, Saab KR, Ma J, Schatton T, P[Character fc]tz P, Zhan Q, Murphy GF, Gasser M, Waaga-Gasser AM, Frank NY, Frank MH. Cancer research. Aug;74:4196-207. [Full Text Article] [PubMed:24934811] [PMC:PMC4119553] Related Antibodies: LS-A806.

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CXCR1 (3)
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CXCR1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
39.6 kDa
20 µg/$150
CXCR1 Protein - 12.5% SDS-PAGE of human CXCR1 stained with Coomassie Blue
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Wheat Germ Extract
GST
64.24 kDa
2 µg/$439
CXCR1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
39.6 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).