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CXCL5

chemokine (C-X-C motif) ligand 5

CXCL5 is a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion.

Gene Name: chemokine (C-X-C motif) ligand 5
Family/Subfamily: Intercrine , Intercrine alpha
Synonyms: CXCL5, C-X-C motif chemokine 5, ENA-78(1-78), GCP-2, ENA78, SCYB5, ENA-78, Small inducible cytokine B5, Small-inducible cytokine B5, LIX, AMCF-II
Target Sequences: NM_002994 NP_002985.1 P42830

Publications (4)

1
A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy. Balamayoora Theivanthiran, Kathy S Evans, Nicholas C DeVito, Michael Plebanek, Michael Sturdivant, Luke P Wachsmuth, April Ks Salama, Yubin Kang, David Hsu, Justin M Balko, Douglas B Johnson, Mark Starr, Andrew B Nixon, Alisha Holtzhausen, Brent A Hanks. The Journal of clinical investigation. 2020 May;130:2570-2586. [Full Text Article] [PubMed:32017708] [PMC:PMC7190922] Related Antibodies: LS-C293780.
2
Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils. Karim Mahiddine, Adam Blaisdell, Stephany Ma, Amandine Créquer-Grandhomme, Clifford A Lowell, Adrian Erlebacher. The Journal of clinical investigation. 2020 Jan;130:389-403. [Full Text Article] [PubMed:31600172] [PMC:PMC6934192] Related Antibodies: LS-C212192.
3
Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy. Nicholas C DeVito, Michael Sturdivant, Balamayooran Thievanthiran, Christine Xiao, Michael P Plebanek, April K S Salama, Georgia M Beasley, Alisha Holtzhausen, Veronica Novotny-Diermayr, John H Strickler, Brent A Hanks. Cell reports. 2021 May;35:109071. [Full Text Article] [PubMed:33951424] [PMC:PMC8148423] Related Antibodies: LS-C104413.
4
Inflammogenic effect of polyacrylic acid in rat lung following intratracheal instillation. Chinatsu Nishida, Taisuke Tomonaga, Hiroto Izumi, Ke-Yong Wang, Hidenori Higashi, Toru Ishidao, Jun-Ichi Takeshita, Ryohei Ono, Kazuki Sumiya, Shota Fujii, Shinichi Mochizuki, Kazuo Sakurai, Kei Yamasaki, Kazuhiro Yatera, Yasuo Morimoto. Particle and fibre toxicology. 2022 January;19:8. [Full Text Article] [PubMed:35062982] [PMC:PMC8780717]
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).