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CXCL4 / PF4
platelet factor 4
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.
| Gene Name: | platelet factor 4 |
| Family/Subfamily: | Intercrine , Intercrine alpha |
| Synonyms: | PF4, C-X-C motif chemokine 4, CXCL4, Iroplact, Oncostatin-A, PF-4, SCYB4, Platelet factor 4 |
| Target Sequences: | NM_002619 NP_002610.1 P02776 |
Publications (1)
1
Therapeutic potential of fibrinogen ?-chain peptide-coated, ADP-encapsulated liposomes as a haemostatic adjuvant for post-cardiopulmonary bypass coagulopathy. Osamu Ishida, Kohsuke Hagisawa, Nozomu Yamanaka, Koji Tsutsumi, Hidenori Suzuki, Masato Takikawa, Shinji Takeoka, Manabu Kinoshita. Scientific reports. 2020 July;10:11308. [Full Text Article]
[PubMed:32647296]
[PMC:PMC7347858]
☰ Filters
Products
Proteins
(24)
Type
Over-Expression Lysate
(2)
Recombinant
(22)
Target
CXCL4 / PF4
(24)
Publications
No
(24)
Tag
6His, C-terminus
(2)
6His-SUMO, N-terminus
(1)
GST
(1)
GST, N-terminus
(1)
His
(3)
His, N-Terminal
(1)
His-GST
(1)
His-S
(1)
His-T7
(1)
Myc-DDK (Flag)
(3)
Species
Human
(13)
Mouse
(7)
Rat
(3)
Source
293T Cells
(1)
E. coli
(16)
HEK 293 Cells
(3)
Human Cells
(1)
Mammalian Cells
(1)
Wheat Germ Extract
(2)
Purification
Purified
(10)
Low Endotoxin Level
Low endotoxin level
(10)
Biologically Active
Biologically active
(8)
E. coli
His, N-Terminal
13.5 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
8.5kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
HEK 293 Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
~7.8 kDa (SDS-PAGE)
50 µg/$364; 10 µg/$278
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 70 amino acid recombinant protein has a predicted molecular mass of approximately 7.8 kD. The DTT-reduced and non-reduced protein migrates at approximately 11 kD by SDS-PAGE. The predicted N-terminal amino acid is Glu.
25 µg/$375; 100 µg/$731
E. coli
None
Less than 0.01 ng/µg (determined by LAL method).
The 76 amino acid recombinant protein has a predicted molecular mass of approximately 8.2 kD. The DTT-reduced and non-reduced protein migrate at approximately 13 and 14 kD by SDS-PAGE respectively. The N-terminal amino acid is Valine.
10 µg/$306; 25 µg/$375; 100 µg/$731; 500 µg/$1,614
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Wheat Germ Extract
GST
37.2 kDa
10 µg/$479; 25 µg/$670
E. coli
His
20 µg/$361; 100 µg/$543; 10 µg/$294; 50 µg/$409; 250 µg/$946; 500 µg/$1,437
E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
HEK 293 Cells
Myc-DDK (Flag)
10.7 kDa
20 µg/$1,107
293T Cells
Myc-DDK (Flag)
10.7 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
10.7 kDa
100 µg/$494
E. coli
None
Biologically active
7.8 kDa
5 µg/$286; 100 µg/$1,018; 500 µg/$1,891
E. coli
None
Biologically active
8.2 kDa
5 µg/$282; 100 µg/$1,116; 500 µg/$2,095
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
7.8 kDa
5 µg/$268; 20 µg/$349
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
8.2 kDa
5 µg/$268; 20 µg/$349
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~9 kDa
20 µg/$432; 1 mg/$4,915
E. coli
75 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
8.36 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
8.5 kDa
10 µg/$288; 50 µg/$436
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~8 kDa
20 µg/$432; 1 mg/$4,915
E. coli
His-T7
12.0 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
E. coli
His
10.2 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
E. coli
His-GST
41.9 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
E. coli
His-S
14.0 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
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