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Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
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CXCL1 / GRO Alpha

chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

GRO Alpha (CXCL1), a small cytokine belonging to the CXC chemokine family, secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. GRO alpha is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. GRO Alpha plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2. An initial study in mice showed evidence that GRO alpha decreased the severity of multiple sclerosis and may offer a neuro-protective function.

Gene Name: chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Family/Subfamily: Intercrine , Intercrine alpha
Synonyms: CXCL1, C-X-C motif chemokine 1, Fibroblast secretory protein, FSP, GRO1, GROa, Growth-regulated alpha protein, GRO-alpha(1-73), MGSA, MGSA-a, Small inducible cytokine b1, GRO, MGSA alpha, NAP-3, SCYB1
Target Sequences: NM_001511 NP_001502.1 P09341

Publications (5)

1
Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFa-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, Usami I, Sakamoto S, Abe H, Watanabe T, Yamori T, Shibasaki M, Nomoto A. PloS one. 2015 10:e0119415. (IHC; Human) [Full Text Article] [PubMed:25785838] [PMC:PMC4364666] Related Antibodies: LS-C104351.
2
Developmental regulation of the neuroinflammatory responses to LPS and/or hypoxia-ischemia between preterm and term neonates: An experimental study. Brochu ME, Girard S, Lavoie K, Sébire G. Journal of neuroinflammation. 2011 8:55. (WB; Rat) [Full Text Article] [PubMed:21599903]
3
3'-Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis. Kang LJ, Kwon ES, Lee KM, Cho C, Lee JI, Ryu YB, Youm TH, Jeon J, Cho MR, Jeong SY, Lee SR, Kim W, Yang S. British journal of pharmacology. 2018 December;175:4295-4309. [Full Text Article] [PubMed:30152858] [PMC:PMC6240131]
4
In vivo imaging reveals unique neutrophil transendothelial migration patterns in inflamed intestines. Sullivan DP, Bui T, Muller WA, Butin-Israeli V, Sumagin R. Mucosal immunology. 2018 November;11:1571-1581. [Full Text Article] [PubMed:30104624] [PMC:PMC6279495]
5
Activation of TGR5 alleviates inflammation in rheumatoid arthritis peripheral blood mononuclear cells and in mice with collagen II-induced arthritis. Li ZY, Zhou JJ, Luo CL, Zhang LM. Molecular medicine reports. 2019 November;20:4540-4550. [Full Text Article] [PubMed:31702035] [PMC:PMC6797944]
more


CXCL1 / GRO Alpha Protein - Eukaryotic Neutrophil Activating Protein 3 (NAP3) by SDS-PAGE
Select
293F Cells
His, N-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
12kDa
10µg   $315.00; 50µg   $590.00; 200µg   $1,170.00; 100µg   $935.00; 1mg   $3,510.00
CXCL1 / GRO Alpha Protein
Select
E. coli
His, N-Terminal
7.8 kDa
50µg   $325.00
Select
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
7.8 kDa
1mg   $2,670.00; 25µg   $295.00
Select
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
7.9 kDa
1mg   $2,670.00; 25µg   $295.00
Select
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
7.8 kDa
1mg   $2,670.00; 20µg   $295.00
Select
E. coli
None
7.8 kDa
5µg   $225.00; 25µg   $295.00
CXCL1 / GRO Alpha Protein
Select
E. coli
None
Biologically active
7.8 kDa
5µg   $225.00; 25µg   $315.00; 100µg   $770.00; 250µg   $1,380.00; 1mg   $2,445.00; 500µg   $1,785.00
CXCL1 / GRO Alpha Protein
Select
E. coli
None
Biologically active
7.8 kDa
5µg   $225.00; 20µg   $315.00; 100µg   $770.00; 250µg   $1,380.00; 1mg   $2,445.00; 500µg   $1,785.00
CXCL1 / GRO Alpha Protein
Select
E. coli
None
Biologically active
7.9 kDa
5µg   $225.00; 25µg   $315.00; 100µg   $770.00; 250µg   $1,380.00; 1mg   $2,445.00; 500µg   $1,785.00
CXCL1 / GRO Alpha Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10µg   $425.00; 25µg   $590.00; 2µg   $385.00
Select
CHO Cells
None
Less than 0.2 EU/µg protein (determined by LAL method).
5-7 kDa (SDS-PAGE)
5µg   $195.00; 25µg   $235.00; 1mg   $1,395.00
CXCL1 / GRO Alpha Protein
Select
E. coli
His
100µg   0.5mg/ml   $365.00; 0.5mg   0.5mg/ml   $935.00
Select
E. coli
His
11.6 kD
1mg   $1,845.00; 100µg   $445.00; 20µg   $315.00
CXCL1 / GRO Alpha Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, C-terminus
10.6 kDa
1mg   $1,290.00; 100µg   $355.00; 20µg   $265.00
CXCL1 / GRO Alpha Protein - Human neutrophils chemoattracted by mouse CXCL1.
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 68 amino acid recombinant protein has a predicted molecular mass of approximately 7.4 kD. The DTT-reduced protein migrates at approximately 10 kD and non-reduced protein migrates at slightly higher than 10 kD by SDS-PAGE. The N-terminal amino acid is
10µg   0.2mg/ml   $255.00; 25µg   0.2mg/ml   $375.00; 100µg   $980.00; 500µg   $2,535.00
CXCL1 / GRO Alpha Protein - Neutrophils chemoattracted by human CXCL1.
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 73 amino acid recombinant protein has a predicted molecular mass of approximately 7.8 kD. The DTT-reduced protein migrates at approximately 10 kD and non-reduced protein migrates at slightly higher than 10 kD by SDS-PAGE. The N-terminal amino acid is
10µg   0.2mg/ml   $225.00; 25µg   0.2mg/ml   $285.00; 100µg   $590.00; 500µg   $1,755.00
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
7.8 kDa
5µg   $215.00; 20µg   $285.00
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
7.8 kDa
5µg   $215.00; 25µg   $285.00
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
7.8 kDa
5µg   $215.00; 25µg   $285.00
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein.
7.8 kDa
25µg   $425.00; 1mg   $7,365.00
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein.
7.8 kDa
20µg   $335.00; 1mg   $4,725.00; 100µg   $890.00
Select
None
7.8 kD
20µg   $395.00
Select
E. coli
None
Biologically active
Less than 0.1 EU/µg protein.
25µg   $425.00; 5µg   $265.00
CXCL1 / GRO Alpha Protein - 12.5% SDS-PAGE of human CXCL1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
37.7 kDa
10µg   $425.00; 25µg   $590.00; 2µg   $385.00
CXCL1 / GRO Alpha Protein - 12.5% SDS-PAGE of human CXCL1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
37.51 kDa
10µg   $425.00; 25µg   $590.00; 2µg   $385.00
Viewing 1-25 of 44 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).