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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CXCL1 / GRO Alpha

chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

GRO Alpha (CXCL1), a small cytokine belonging to the CXC chemokine family, secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. GRO alpha is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. GRO Alpha plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2. An initial study in mice showed evidence that GRO alpha decreased the severity of multiple sclerosis and may offer a neuro-protective function.

Gene Name: chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Family/Subfamily: Intercrine , Intercrine alpha
Synonyms: CXCL1, C-X-C motif chemokine 1, Fibroblast secretory protein, FSP, GRO1, GROa, Growth-regulated alpha protein, GRO-alpha(1-73), MGSA, MGSA-a, Small inducible cytokine b1, GRO, MGSA alpha, NAP-3, SCYB1
Target Sequences: NM_001511 NP_001502.1 P09341

Publications (3)

1
Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFa-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, Usami I, Sakamoto S, Abe H, Watanabe T, Yamori T, Shibasaki M, Nomoto A. PloS one. 2015 10:e0119415. (IHC; Human) [Full Text Article] [PubMed:25785838] [PMC:PMC4364666] Related Antibodies: LS-C104351.
2
Developmental regulation of the neuroinflammatory responses to LPS and/or hypoxia-ischemia between preterm and term neonates: An experimental study. Brochu ME, Girard S, Lavoie K, Sébire G. Journal of neuroinflammation. 2011 8:55. (WB; Rat) [Full Text Article] [PubMed:21599903]
3
3'-Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis. Kang LJ, Kwon ES, Lee KM, Cho C, Lee JI, Ryu YB, Youm TH, Jeon J, Cho MR, Jeong SY, Lee SR, Kim W, Yang S. British journal of pharmacology. 2018 December;175:4295-4309. [Full Text Article] [PubMed:30152858] [PMC:PMC6240131]

Filtered by: None
Type
Over-Expression Lysate (1)
Recombinant (44)
Target
CXCL1 / GRO Alpha (45)
Tag
6His + SUMO,N-terminus (1)
6His,C-terminus (3)
6His,N-terminus (1)
GST (2)
GST,N-terminus (1)
His (6)
His + GST (2)
His + MBP (1)
His + T7 (1)
His, N-Terminal (1)
Myc + DDK (1)
Species
Human (21)
Mouse (17)
Rat (6)
Source
293F Cells (1)
293T Cells (1)
CHO Cells (2)
E. coli (34)
HEK 293 Cells (1)
Human Cells (2)
Wheat Germ Extract (3)
Purification
Purified (40)
Low Endotoxin Level
Low endotoxin level (20)
Biologically Active
Biologically active (24)
Publications
No (45)
Showing 1-25 of 45 results

Rat CXCL1 / GRO Alpha Protein (Recombinant) - LS-G16565
E. coli
None
Biologically active
5µg  $195.00; 25µg  $255.00; 1mg  $2,850.00

Human CXCL1 / GRO Alpha Protein (Recombinant) - LS-G16519
E. coli
None
Biologically active
5µg  $195.00; 25µg  $255.00; 1mg  $2,850.00

Mouse CXCL1 / GRO Alpha Protein (Recombinant) - LS-G16525
E. coli
None
Biologically active
5µg  $195.00; 20µg  $255.00; 1mg  $2,850.00

Mouse CXCL1 / GRO Alpha Protein (Recombinant) - LS-G27104
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
5-7 kDa (SDS-PAGE)
5µg  $195.00; 25µg  $235.00; 1mg  $1,395.00

Human CXCL1 / GRO Alpha Protein (Recombinant GST) (Full Length) - LS-G28724
Wheat Germ Extract
GST
37.7 kDa
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE of human CXCL1 stained with Coomassie Blue

Human CXCL1 / GRO Alpha Protein (Recombinant GST) (Full Length) - LS-G28723
Wheat Germ Extract
GST
37.51 kDa
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE of human CXCL1 stained with Coomassie Blue

Mouse CXCL1 / GRO Alpha Protein (Recombinant) - LS-G37840
None
7.8 kD
20µg  $395.00

Mouse CXCL1 / GRO Alpha Protein (Recombinant His, N-Terminal) (Ala25-Lys96) - LS-G132936
293F Cells
His, N-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
12kDa
10µg  $315.00; 50µg  $590.00; 200µg  $1,170.00; 100µg  $935.00; 1mg  $3,510.00; 500µg  $1,560.00
Eukaryotic Neutrophil Activating Protein 3 (NAP3) by SDS-PAGE

Human CXCL1 / GRO Alpha Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G87906
293T Cells
Myc + DDK
11.3 kDa
20µg  $195.00

Mouse CXCL1 / GRO Alpha Protein (Recombinant His) - LS-G16417
E. coli
His
5µg  $195.00; 20µg  $255.00; 1mg  $3,780.00

Human CXCL1 / GRO Alpha Protein (Recombinant His) - LS-G16455
E. coli
His
10µg  $195.00; 50µg  $255.00; 1mg  $1,890.00

Human CXCL1 / GRO Alpha Protein (Recombinant 6His + SUMO,N-terminus) (aa35-107) - LS-G56691
E. coli
6His + SUMO,N-terminus
1mg  $1,290.00; 500µg  $830.00; 200µg  $485.00; 100µg  $355.00; 50µg  $275.00; 10µg  $245.00
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Human CXCL1 / GRO Alpha Protein (Recombinant GST,N-terminus) (aa36-107) - LS-G58766
Wheat Germ Extract
GST,N-terminus
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE Stained with Coomassie Blue.

Mouse CXCL1 / GRO Alpha Protein (Recombinant His) (aa29-96) - LS-G22452
E. coli
His
11.6 kD
1mg  $1,845.00; 500µg  $1,185.00; 200µg  $710.00; 50µg  $325.00; 10µg  $275.00; 100µg  $445.00

Human CXCL1 / GRO Alpha Protein (Recombinant His) (aa35-107) - LS-G22306
E. coli
His
12 kD
1mg  $1,290.00; 500µg  $830.00; 200µg  $485.00; 50µg  $275.00; 10µg  $245.00; 100µg  $355.00

Human CXCL1 / GRO Alpha Protein (Recombinant) - LS-G133841
E. coli
None
Biologically active
7.8 kDa
5µg  $225.00; 25µg  $295.00

Human CXCL1 / GRO Alpha Protein (Recombinant 6His,C-terminus) (Full Length) - LS-G136987
E. coli
6His,C-terminus
10.6 kDa
1mg  $1,290.00; 500µg  $830.00; 200µg  $485.00; 100µg  $355.00; 50µg  $275.00; 10µg  $245.00
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Human CXCL1 / GRO Alpha Protein (Recombinant) - LS-G23606
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
7.9 kDa
100µg  $445.00; 1mg  $3,030.00; 25µg  $275.00; 500µg  $1,815.00; 5µg  $205.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Chemotaxis Image

Human CXCL1 / GRO Alpha Protein (Recombinant) (Full Length) - LS-G136688
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
8.6 kDa
1mg  $2,445.00; 500µg  $1,710.00; 50µg  $325.00; 10µg  $215.00
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Human CXCL1 / GRO Alpha Protein (Recombinant) - LS-G131244
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~8 kDa
25µg  $205.00; 200µg  $445.00; 1mg  $1,770.00

Mouse CXCL1 / GRO Alpha Protein (Recombinant) - LS-G131537
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~8 kDa
25µg  $205.00; 100µg  $315.00; 1mg  $1,770.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

Rat CXCL1 / GRO Alpha Protein (Recombinant) - LS-G131574
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~8 kDa
25µg  $205.00; 100µg  $305.00; 1mg  $1,050.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

Human CXCL1 / GRO Alpha Protein (Recombinant 6His,C-terminus) (Ala35-Asn107) - LS-G39087
Human Cells
6His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
8.9kD
10µg  $245.00; 50µg  $405.00; 500µg  $1,290.00; 1mg  $1,845.00

Mouse CXCL1 / GRO Alpha Protein (Recombinant 6His,C-terminus) (Arg20-Lys96) - LS-G39184
Human Cells
6His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
9.4kD
10µg  $235.00; 50µg  $385.00; 500µg  $1,605.00; 1mg  $2,310.00

Mouse CXCL1 / GRO Alpha Protein (Recombinant) - LS-G137765
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 68 amino acid recombinant protein has a predicted molecular mass of approximately 7.4 kD. The DTT-reduced protein migrates at approximately 10 kD and non-reduced protein migrates at slightly higher than 10 kD by SDS-PAGE. The N-terminal amino acid is
10µg 0.2mg/ml  $255.00; 25µg 0.2mg/ml  $375.00; 100µg  $980.00; 500µg  $2,535.00
Human neutrophils chemoattracted by mouse CXCL1.
Showing 1-25 of 45 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).