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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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CXCL1 / GRO Alpha

chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

GRO Alpha (CXCL1), a small cytokine belonging to the CXC chemokine family, secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. GRO alpha is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. GRO Alpha plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2. An initial study in mice showed evidence that GRO alpha decreased the severity of multiple sclerosis and may offer a neuro-protective function.

Gene Name: chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Family/Subfamily: Intercrine , Intercrine alpha
Synonyms: CXCL1, C-X-C motif chemokine 1, Fibroblast secretory protein, FSP, GRO1, GROa, Growth-regulated alpha protein, GRO-alpha(1-73), MGSA, MGSA-a, Small inducible cytokine b1, GRO, MGSA alpha, NAP-3, SCYB1
Target Sequences: NM_001511 NP_001502.1 P09341

Publications (5)

1
Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFa-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, Usami I, Sakamoto S, Abe H, Watanabe T, Yamori T, Shibasaki M, Nomoto A. PloS one. 2015 10:e0119415. (IHC; Human) [Full Text Article] [PubMed:25785838] [PMC:PMC4364666] Related Antibodies: LS-C104351.
2
Developmental regulation of the neuroinflammatory responses to LPS and/or hypoxia-ischemia between preterm and term neonates: An experimental study. Brochu ME, Girard S, Lavoie K, Sébire G. Journal of neuroinflammation. 2011 8:55. (WB; Rat) [Full Text Article] [PubMed:21599903]
3
3'-Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis. Kang LJ, Kwon ES, Lee KM, Cho C, Lee JI, Ryu YB, Youm TH, Jeon J, Cho MR, Jeong SY, Lee SR, Kim W, Yang S. British journal of pharmacology. 2018 December;175:4295-4309. [Full Text Article] [PubMed:30152858] [PMC:PMC6240131]
4
In vivo imaging reveals unique neutrophil transendothelial migration patterns in inflamed intestines. Sullivan DP, Bui T, Muller WA, Butin-Israeli V, Sumagin R. Mucosal immunology. 2018 November;11:1571-1581. [Full Text Article] [PubMed:30104624] [PMC:PMC6279495]
5
Activation of TGR5 alleviates inflammation in rheumatoid arthritis peripheral blood mononuclear cells and in mice with collagen II-induced arthritis. Li ZY, Zhou JJ, Luo CL, Zhang LM. Molecular medicine reports. 2019 November;20:4540-4550. [Full Text Article] [PubMed:31702035] [PMC:PMC6797944]
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CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
0.614 - 150 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1plate   $470.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich
96-Well Microplate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1plate   $580.00
CXCL1 / GRO Alpha ELISA Kit
Select
Development Kit
200 Wells
Mouse
4 - 1000 pg/ml
Colorimetric - 405nm (ABTS)
1tst   $180.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
15.625 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate   $555.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1plate   $580.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Human
4 - 250 pg/ml
Chemiluminescent
Cell Lysates, Plasma, Serum
1plate   $520.00
CXCL1 / GRO Alpha ELISA Kit
Select
Development Kit
1000 Wells
Human
16 - 1000 pg/ml
Colorimetric - 405nm (ABTS)
1tst   $540.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1plate   $700.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1plate   $540.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
234.4 - 7500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1plate   $470.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Human
16 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1plate   $490.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Rat
16 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1plate   $490.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Serum
1plate   $580.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1plate   $580.00
CXCL1 / GRO Alpha ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1plate   $650.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Human
1.37 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1plate   $940.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Rat
1.37 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1plate   $1,010.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Mouse
1.37 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1plate   $960.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Serum
1plate   $580.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1plate   $580.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $530.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $530.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich
96-Well Microplate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $530.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $650.00
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $650.00
Viewing 1-25 of 57 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).