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CXCL1 / GRO Alpha
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
GRO Alpha (CXCL1), a small cytokine belonging to the CXC chemokine family, secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. GRO alpha is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. GRO Alpha plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2. An initial study in mice showed evidence that GRO alpha decreased the severity of multiple sclerosis and may offer a neuro-protective function.
| Gene Name: | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
| Family/Subfamily: | Intercrine , Intercrine alpha |
| Synonyms: | CXCL1, C-X-C motif chemokine 1, Fibroblast secretory protein, FSP, GRO1, GROa, Growth-regulated alpha protein, GRO-alpha(1-73), MGSA, MGSA-a, Small inducible cytokine b1, GRO, MGSA alpha, NAP-3, SCYB1 |
| Target Sequences: | NM_001511 NP_001502.1 P09341 |
Publications (6)
1
Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFa-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, Usami I, Sakamoto S, Abe H, Watanabe T, Yamori T, Shibasaki M, Nomoto A. PloS one. 2015 10:e0119415. (IHC; Human)
[Full Text Article]
[PubMed:25785838]
[PMC:PMC4364666]
Related Antibodies: LS-C104351.
2
Developmental regulation of the neuroinflammatory responses to LPS and/or hypoxia-ischemia between preterm and term neonates: An experimental study. Brochu ME, Girard S, Lavoie K, Sébire G. Journal of neuroinflammation. 2011 8:55. (WB; Rat)
[Full Text Article]
[PubMed:21599903]
3
3'-Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis. Kang LJ, Kwon ES, Lee KM, Cho C, Lee JI, Ryu YB, Youm TH, Jeon J, Cho MR, Jeong SY, Lee SR, Kim W, Yang S. British journal of pharmacology. 2018 December;175:4295-4309. [Full Text Article]
[PubMed:30152858]
[PMC:PMC6240131]
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CXCL1 / GRO Alpha Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, Neut, WB
Unconjugated
0.1 mg/$495
CXCL1 / GRO Alpha Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
CXCL1 / GRO Alpha Mouse anti-Human Monoclonal (aa36-107) (7A11) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$680
CXCL1 / GRO Alpha Rabbit anti-Human Polyclonal (Pro88) Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
50 µl/$321; 100 µl/$403
CXCL1 / GRO Alpha Mouse anti-Human Monoclonal (2D7) Antibody
Human
ELISA
Unconjugated
100 µg/$423
CXCL1 / GRO Alpha Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
CXCL1 / GRO Alpha Rabbit anti-Rat Polyclonal (Biotin) Antibody
Rat
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
CXCL1 / GRO Alpha Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
CXCL1 / GRO Alpha Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
CXCL1 / GRO Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CXCL1 / GRO Alpha Mouse anti-Human Monoclonal (aa36-107) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$445
CXCL1 / GRO Alpha Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
CXCL1 / GRO Alpha Rabbit anti-Mouse Polyclonal (HRP) Antibody
Mouse
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
CXCL1 / GRO Alpha Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
CXCL1 / GRO Alpha Rabbit anti-Mouse Polyclonal (FITC) Antibody
Mouse
ELISA, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
CXCL1 / GRO Alpha Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
CXCL1 / GRO Alpha Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, Neut, WB
HRP Conjugated
100 µl/$860
CXCL1 / GRO Alpha Rabbit anti-Mouse Polyclonal (aa25-96) Antibody
Mouse
WB
Unconjugated
100 µl/$291; 200 µl/$326; 500 µl/$441; 1 ml/$499; 2 ml/$622; 5 ml/$1,067
CXCL1 / GRO Alpha Rabbit anti-Mouse Polyclonal (aa25-96) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$372; 200 µl/$441; 500 µl/$709; 1 ml/$869; 2 ml/$1,118; 5 ml/$2,017
CXCL1 / GRO Alpha Rabbit anti-Human Monoclonal (Preservative Free) (012) Antibody
Human
ELISA
Unconjugated, Preservative Free
100 µl/$412
CXCL1 / GRO Alpha Rabbit anti-Mouse Polyclonal (aa25-96) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$299; 200 µl/$337; 500 µl/$464; 1 ml/$527
CXCL1 / GRO Alpha Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
CXCL1 / GRO Alpha Mouse anti-Human Monoclonal (aa36-107) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$705
CXCL1 / GRO Alpha Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$904
CXCL1 / GRO Alpha Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
100 µl/$904
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product results
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