CUL7

cullin 7

Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). Does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions.

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Antibodies (20)

Proteins (1)

Type

Primary (20)

Recombinant (1)

Target

CUL7 (21)

Reactivity

Human (20)

Mouse (4)

Rat (1)

Bat (1)

Monkey (1)

Application

IHC (5)

IHC-P (3)

WB (13)

ELISA (15)

ICC (1)

IF (1)

IP (4)

Peptide-ELISA (1)

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rabbit (14)

mouse (6)

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Isotype

IgG (11)

IgG1,k (6)

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monoclonal mc (6)

polyclonal pc (14)

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APC Conjugated (1)

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FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (12)

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aa1650-C-term (2)

aa1-100 (1)

aa1370-1698 (1)

aa1500-1550 (1)

aa1675-1698 (1)

aa1681-1697 (1)

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Yes (1)

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GST, N-terminus (1)

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Human (1)

Source

Wheat Germ Extract (1)

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IHC-plus™ CUL7 Antibody (aa1675-1698) LS-B362

(5.0) Rating

(2) Publication(s)

Antibody:

CUL7 Rabbit anti-Human Polyclonal (aa1675-1698) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$515

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CUL7 Antibody (aa1-100) LS-C307131

Antibody:

CUL7 Mouse anti-Human Monoclonal (aa1-100) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$705

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CUL7 Antibody (HRP) LS-C541662

Antibody:

CUL7 Mouse anti-Human Monoclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

100 µl/$904

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CUL7 Antibody (Biotin) LS-C521530

Antibody:

CUL7 Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

100 µl/$904

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CUL7 Antibody (FITC) LS-C531574

Antibody:

CUL7 Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

100 µl/$904

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CUL7 Antibody (PE) LS-C649774

Antibody:

CUL7 Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

100 µl/$904

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CUL7 Antibody (APC) LS-C513315

Antibody:

CUL7 Mouse anti-Human Monoclonal (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

100 µl/$904

• Unconjugated
• HRP
• Biotin
• FITC
• PE
• APC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE
  • APC

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CUL7 Antibody (aa1500-1550) LS-C287138

Antibody:

CUL7 Rabbit anti-Human Polyclonal (aa1500-1550) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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CUL7 Antibody LS-C680333

Antibody:

CUL7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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CUL7 Antibody (HRP) LS-C680335

Antibody:

CUL7 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

CUL7 Antibody (Biotin) LS-C680336

Antibody:

CUL7 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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CUL7 Antibody (FITC) LS-C680339

Antibody:

CUL7 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

CUL7 Antibody (aa1370-1698) LS-C186334

Antibody:

CUL7 Rabbit anti-Human Polyclonal (aa1370-1698) Antibody

Reactivity:

Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

Select

CUL7 Antibody LS-C664871

Antibody:

CUL7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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CUL7 Antibody LS-C400686

Antibody:

CUL7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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CUL7 Antibody (aa1681-1697) LS-C90304

Antibody:

CUL7 Rabbit anti-Human Polyclonal (aa1681-1697) Antibody

Reactivity:

Bat, Human, Monkey

Applications:

ELISA, WB

Format:

Unconjugated

Price:

1 mg/$901

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CUL7 Antibody LS-C779634

Antibody:

CUL7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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CUL7 Antibody LS-C804019

Antibody:

CUL7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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CUL7 Antibody (aa1650-C-term) LS-C287139

Antibody:

CUL7 Rabbit anti-Human Polyclonal (aa1650-C-term) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

Select

CUL7 Antibody (aa1650-C-term) LS-C287320

Antibody:

CUL7 Rabbit anti-Human Polyclonal (aa1650-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

Select

Human CUL7 Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G61253

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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