LSBio
Products
  • Antibodies
  • All Antibodies
  • Primary Antibodies
  • Secondary Antibodies
  • IHC-plus Antibodies
  • Isotype Control Antibodies
  • ELISA and Assay Kits
  • All Kits
  • Assay Kits
  • Traditional ELISA Kits
  • Cell-Based ELISA Kits
  • DNA-Binding ELISA Kits
  • Phospho-Specific ELISA Kits
  • ELISA Development Kits
  • Chemiluminescent CLIA Kits
  • Proteins
  • All Proteins
  • Recombinant Proteins
  • Native Proteins
  • Over-expression Lysates
  • Cell and Tissue Lysates
  • Bio-active Proteins
  • Animal-free Proteins
  • Synthetic Peptides
  • Biochemicals
  • All Biochemicals

  • Immunohistochemistry
  • Comprehensive IHC Reports
  • Custom IHC Services
  • TCR Screening Services
  • IHC-plus Antibodies
Services
  • Immunohistochemistry Services

  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

  • TCR Screening Services

  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Have a question? CustomerSupport@LSBio.com
Resources
  • Purchasing
  • Product Ordering Terms and Conditions
  • Holiday Schedule
  • About the LSBio Guarantee
  • About Our Rewards Program
  • Reference Material
  • About LSBio (LifeSpan BioSciences Inc.)
  • About Our 2-million Specimen Tissue Bank
  • About Our IHC Validation Process
  • About Our IHC-plus™ Immunohistochemistry Protocol
  • Protocols
  • Secure Logins
  • Login to Our Secure ShareFile Site
  • Login to Our IHC Database
Distributors
Contact Us

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)
How to Buy - Details about how to buy our products.

Orders@LSBio.com - To submit a new order.

Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues.

Technical.Support@LSBio.com - To request technical information requests about an LSBio product or its application.

Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login ▾
Wish List
View Cart

Unfortunately, the antibody (ID:64620) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



CUL7

cullin 7

Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). Does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions.

Gene Name: cullin 7
Synonyms: CUL7, Cullin 7, Cullin-7, CUL-7, DJ20C7.5, KIAA0076
Target Sequences: NM_014780 NP_055595.2 Q14999

Publications (2)

1
CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. Dias DC, Dolios G, Wang R, Pan ZQ. Proceedings of the National Academy of Sciences of the United States of America. 2002 99:16601-6. [PubMed:12481031] [PMC:PMC139190] Related Antibodies: LS-B362.
2
Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA. Proceedings of the National Academy of Sciences of the United States of America. 2003 100:9855-60. [PubMed:12904573] [PMC:PMC187864] Related Antibodies: LS-B362.

Loading ...

Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
CUL7 Rabbit Polyclonal Unconjugated Human IHC-P, WB, IP, ELISA C-Terminus
1
CUL7 Rabbit Polyclonal Unconjugated Human IHC-P, WB, IP, ELISA C-Terminus Yes Primary
Anti-CUL7 Antibody (C-Terminus) IHC-plus™ LS-B362
PublicationsPublications (2)
Immunohistochemistry Image
Rabbit Polyclonal to Human CUL7
Human
IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Unconjugated
CUL7 Rabbit IgG Polyclonal Unconjugated Human IHC-P, ICC, WB aa1370-1698
1
CUL7 Rabbit IgG Polyclonal Unconjugated Human IHC-P, ICC, WB aa1370-1698 No Primary
Anti-CUL7 Antibody (aa1370-1698) LS-C186334
Immunohistochemistry Image
Immunocytochemistry Image
Rabbit Polyclonal (IgG) to Human CUL7
Human
IHC - Paraffin, ICC, Western blot
Unconjugated
CUL7 Rabbit IgG Polyclonal Unconjugated Human, Rat IHC, ELISA
1
CUL7 Rabbit IgG Polyclonal Unconjugated Human, Rat IHC, ELISA No Primary
Anti-CUL7 Antibody LS-C403942
Immunohistochemistry Image
Rabbit Polyclonal (IgG) to Human CUL7
Human, Rat
IHC, ELISA
Unconjugated
CUL7 Mouse IgG1,k Monoclonal Unconjugated,HRP Conjugated,Biotin Conjugated,FITC Conjugated,PE Conjugated,AP Conjugated,APC Conjugated Human WB, ELISA,WB, ELISA,WB, ELISA,WB, ELISA,WB, ELISA,WB, ELISA,WB, ELISA aa1-100
7
CUL7 Mouse IgG1,k Monoclonal Unconjugated Human WB, ELISA aa1-100 No Primary
Anti-CUL7 Antibody (aa1-100) LS-C307131
Mouse Monoclonal (IgG1,k) to Human CUL7
Human
Western blot, ELISA
Unconjugated
CUL7 Mouse IgG1,k Monoclonal HRP Conjugated Human WB, ELISA No Primary
Anti-CUL7 Antibody (HRP) LS-C541662
Mouse Monoclonal (IgG1,k) to Human CUL7
Human
Western blot, ELISA
HRP Conjugated
CUL7 Mouse IgG1,k Monoclonal Biotin Conjugated Human WB, ELISA No Primary
Anti-CUL7 Antibody (Biotin) LS-C521530
Mouse Monoclonal (IgG1,k) to Human CUL7
Human
Western blot, ELISA
Biotin Conjugated
CUL7 Mouse IgG1,k Monoclonal FITC Conjugated Human WB, ELISA No Primary
Anti-CUL7 Antibody (FITC) LS-C531574
Mouse Monoclonal (IgG1,k) to Human CUL7
Human
Western blot, ELISA
FITC Conjugated
CUL7 Mouse IgG1,k Monoclonal PE Conjugated Human WB, ELISA No Primary
Anti-CUL7 Antibody (PE) LS-C649774
Mouse Monoclonal (IgG1,k) to Human CUL7
Human
Western blot, ELISA
PE Conjugated
CUL7 Mouse IgG1,k Monoclonal AP Conjugated Human WB, ELISA No Primary
Anti-CUL7 Antibody (AP) LS-C503605
Mouse Monoclonal (IgG1,k) to Human CUL7
Human
Western blot, ELISA
AP Conjugated
CUL7 Mouse IgG1,k Monoclonal APC Conjugated Human WB, ELISA No Primary
Anti-CUL7 Antibody (APC) LS-C513315
Mouse Monoclonal (IgG1,k) to Human CUL7
Human
Western blot, ELISA
APC Conjugated
CUL7 Rabbit IgG Polyclonal Unconjugated Human, Rat IHC, ELISA
1
CUL7 Rabbit IgG Polyclonal Unconjugated Human, Rat IHC, ELISA No Primary
Anti-CUL7 Antibody LS-C400686
Immunohistochemistry Image
Immunohistochemistry Image
Rabbit Polyclonal (IgG) to Human CUL7
Human, Rat
IHC, ELISA
Unconjugated
CUL7 Rabbit Polyclonal Unconjugated Human, Monkey, Bat WB, ELISA aa1681-1697
1
CUL7 Rabbit Polyclonal Unconjugated Human, Monkey, Bat WB, ELISA aa1681-1697 No Primary
Anti-CUL7 Antibody (aa1681-1697) LS-C90304
Rabbit Polyclonal to Human CUL7
Human, Monkey, Bat
Western blot, ELISA
Unconjugated
CUL7 Rabbit IgG Polyclonal Unconjugated Human, Mouse WB, IP aa1500-1550
1
CUL7 Rabbit IgG Polyclonal Unconjugated Human, Mouse WB, IP aa1500-1550 No Primary
Anti-CUL7 Antibody (aa1500-1550) LS-C287138
Rabbit Polyclonal (IgG) to Human CUL7
Human, Mouse
Western blot, Immunoprecipitation
Unconjugated
CUL7 Rabbit IgG Polyclonal Unconjugated Human, Rat, Horse, Rabbit IP C-Terminus
1
CUL7 Rabbit IgG Polyclonal Unconjugated Human, Rat, Horse, Rabbit IP C-Terminus No Primary
Anti-CUL7 Antibody (C-Terminus) LS-C287139
Rabbit Polyclonal (IgG) to Human CUL7
Human, Rat, Horse, Rabbit
Immunoprecipitation
Unconjugated
CUL7 Rabbit IgG Polyclonal Unconjugated Human, Mouse IP C-Terminus
1
CUL7 Rabbit IgG Polyclonal Unconjugated Human, Mouse IP C-Terminus No Primary
Anti-CUL7 Antibody (C-Terminus) LS-C287320
Immunoprecipitation Image
Rabbit Polyclonal (IgG) to Human CUL7
Human, Mouse
Immunoprecipitation
Unconjugated

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


Get Social With Us! Follow us on Facebook Follow us on Google+ Follow us on LinkedIn PSL Alliance Member
Copyright © 2017 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy
Catalog Number