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CTTN / Cortactin

cortactin

CTTN / Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.

Gene Name: cortactin
Synonyms: CTTN, Cortactin, EMS1, Oncogene EMS1, Amplaxin, Src substrate cortactin
Target Sequences: NM_005231 NP_005222.2 Q14247

Publications (2)

1
Overexpression and Tyr421-phosphorylation of cortactin is induced by three-dimensional spheroid culturing and contributes to migration and invasion of pancreatic ductal adenocarcinoma (PDAC) cells. Stock K, Borrink R, Mikesch JH, Hansmeier A, Rehkämper J, Trautmann M, Wardelmann E, Hartmann W, Sperveslage J, Steinestel K. Cancer cell international. 2019 March;19:77. [Full Text Article] [PubMed:30976201] [PMC:PMC6441202]
2
The Pathogenic Effect of Cortactin Tyrosine Phosphorylation in Cutaneous Squamous Cell Carcinoma. Zhu L#, Cho E#, Zhao G, Roh MR, Zheng Z. In Vivo. 2019 March-Apri;33:393-400. [Full Text Article] [PubMed:30804117] [PMC:PMC6506328] Related Antibodies: LS-C353975, LS-C381441.

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Products
Proteins (12)
Over-Expression Lysate (6)
Recombinant (6)
CTTN / Cortactin (12)
No (12)
6His, N-terminus (1)
DDK,C-terminus (1)
GST (1)
GST, N-terminus (1)
His-T7 (1)
Myc-DDK (Flag) (7)
Human (7)
Mouse (1)
Rat (1)
293T Cells (3)
E. coli (2)
HEK 293 Cells (4)
Sf9 Cells (1)
Wheat Germ Extract (2)
Purified (1)
CTTN / Cortactin Protein - Recombinant  Cortactin By SDS-PAGE
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E. coli
6His, N-terminus
60.68 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
CTTN / Cortactin Protein - 12.5% SDS-PAGE of human CTTN stained with Coomassie Blue
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Wheat Germ Extract
GST
83.9 kDa
2 µg/$439
CTTN / Cortactin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
61.4 kDa
100 µg/$494
CTTN / Cortactin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
61.4 kDa
100 µg/$710
CTTN / Cortactin Protein
Select
Sf9 Cells
DDK,C-terminus
57.3 kDa
20 µg/$677
CTTN / Cortactin Protein - Recombinant  Cortactin By SDS-PAGE
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E. coli
His-T7
60.6 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
CTTN / Cortactin Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CTTN / Cortactin Protein - Purified recombinant protein CTTN was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
57.3 kDa
20 µg/$1,107
CTTN / Cortactin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
61.4 kDa
20 µg/$215
Select
293T Cells
Myc-DDK (Flag)
61.4 kDa
20 µg/$150
Select
293T Cells
Myc-DDK (Flag)
57.3 kDa
20 µg/$150
CTTN / Cortactin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
57.3 kDa
100 µg/$494
Viewing 1-12 of 12 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).