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CTTN / Cortactin
cortactin
CTTN / Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
| Gene Name: | cortactin |
| Synonyms: | CTTN, Cortactin, EMS1, Oncogene EMS1, Amplaxin, Src substrate cortactin |
| Target Sequences: | NM_005231 NP_005222.2 Q14247 |
Publications (2)
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