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CTSL / Cathepsin L

Cathepsin L

CTSL / Cathepsin L is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.

Gene Name: Cathepsin L
Family/Subfamily: Protease , Cysteine C1
Synonyms: CTSL, Cathepsin L, Cathepsin L1, CATL, CTSL1, Major excreted protein, MEP
Target Sequences: NM_001912 NP_001903.1 P07711

Publications (1)

1
Modulation of Cathepsin L Expression in the Coronary Arteries of Atherosclerotic Swine. Palanikumar Gunasekar, Mohan Satish, Parinaz Dabestani, Wanlin Jiang, Chandra Boosani, Mohammad Radwan, Devendra Agrawal, Juan Asensio. The Journal of surgical research. 2019 November;243:460-468. [Full Text Article] [PubMed:31377485] [PMC:PMC6773494] Related Antibodies: LS-C293267.

☰ Filters
Products
Proteins (22)
Over-Expression Lysate (4)
Recombinant (18)
CTSL / Cathepsin L (22)
Product Group
Coronavirus Antibodies Proteins cDNAs (22)
SARS-CoV-2 Associated Proteins (22)
No (22)
6His, C-terminus (4)
6His, N-terminus + Myc, C-terminus (1)
GST (2)
His (4)
His, N-Terminal (1)
His,C-terminus (1)
His-GST (2)
His-SUMO (1)
Myc-DDK (Flag) (6)
African green monkey (1)
Human (12)
Mouse (5)
Pig (1)
Rat (1)
293T Cells (2)
E. coli (8)
HEK 293 Cells (5)
Human Cells (5)
Wheat Germ Extract (2)
Purified (7)
Low endotoxin level (7)
CTSL / Cathepsin L Protein - Recombinant Cathepsin L By SDS-PAGE
Select
E. coli
His, N-Terminal
20.3 kDa; Observed: 20.6 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.88kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
CTSL / Cathepsin L Protein - Recombinant Cathepsin L By SDS-PAGE
Select
E. coli
His
20.5 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
CTSL / Cathepsin L Protein - Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of Recombinant Mouse Cathepsin L1(Ctsl1),partial could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Ctsl.
Select
E. coli
6His, N-terminus + Myc, C-terminus
26.2 kDa
20 µg/$364; 1 mg/$1,679; 100 µg/$500
CTSL / Cathepsin L Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
35.8 kDa
100 µg/$494
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
37.3 kDa
50 µg/$854
CTSL / Cathepsin L Protein - Purified recombinant protein CTSL was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
35.8 kDa
20 µg/$1,107
CTSL / Cathepsin L Protein - Purified recombinant protein CTSL was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
35.8 kDa
20 µg/$1,107
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.9 kDa
10 µg/$344; 50 µg/$584
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.8 kDa
10 µg/$317; 50 µg/$524
CTSL / Cathepsin L Protein
Select
E. coli
His-SUMO
40.06 kD
1 mg/$1,679; 100 µg/$598; 20 µg/$405
CTSL / Cathepsin L Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
CTSL / Cathepsin L Protein - 12.5% SDS-PAGE of human CTSL stained with Coomassie Blue
Select
Wheat Germ Extract
GST
62.37 kDa
10 µg/$479; 25 µg/$670
CTSL / Cathepsin L Protein - 12.5% SDS-PAGE of human CTSL stained with Coomassie Blue
Select
Wheat Germ Extract
GST
60.39 kDa
10 µg/$479; 25 µg/$670
CTSL / Cathepsin L Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
35.8 kDa
20 µg/$150
CTSL / Cathepsin L Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
37.53 kDa
20 µg/$150
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
37.3 kDa
50 µg/$854
CTSL / Cathepsin L Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
37.53 kDa
100 µg/$494
Select
E. coli
219 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
24.2 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.8kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
CTSL / Cathepsin L Protein - Recombinant Cathepsin L By SDS-PAGE
Select
E. coli
His-GST
38.9 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
CTSL / Cathepsin L Protein - Recombinant Cathepsin L By SDS-PAGE
Select
E. coli
His-GST
50.8 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).