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CTSE / Cathepsin E

cathepsin E

CTSE / Cathepsin E is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene.

Gene Name: cathepsin E
Family/Subfamily: Protease , Aspartic A1
Synonyms: CTSE, CATE, Cathepsin E, Ctsea, Slow-moving proteinase, CEB
Target Sequences: AJ250717 AAA52300.1 P14091

Publications (2)

1
FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer. Camolotto SA, Pattabiraman S, Mosbruger TL, Jones A, Belova VK, Orstad G, Streiff M, Salmond L, Stubben C, Kaestner KH, Snyder EL. eLife. 2018 November;7:pii e38579. [Full Text Article] [PubMed:30475207] [PMC:PMC6303105] Related Antibodies: LS-B523.
2
An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma. Rediet Zewdu , Elnaz Mirzaei Mehrabad , Kelley Ingram , Pengshu Fang , Katherine L Gillis , Soledad A Camolotto , Grace Orstad , Alex Jones , Michelle C Mendoza , Benjamin T Spike , Eric L Snyder. eLife. 2021 Apr;10:e66788. [Full Text Article] [PubMed:33821796] [PMC:PMC8102067] Related Antibodies: LS-B523.

☰ Filters
Products
Proteins (14)
Over-Expression Lysate (4)
Recombinant (10)
CTSE / Cathepsin E (14)
No (14)
6His, C-terminus (5)
GST (1)
His (3)
Myc-DDK (Flag) (4)
Human (8)
Mouse (3)
Rat (1)
293T Cells (2)
E. coli (1)
HEK 293 Cells (3)
Human Cells (4)
Mammalian Cells (3)
Wheat Germ Extract (1)
Purified (4)
Low endotoxin level (8)
Biologically active (1)
CTSE / Cathepsin E Protein - 12.5% SDS-PAGE of human CTSE stained with Coomassie Blue
Select
Wheat Germ Extract
GST
67.43 kDa
10 µg/$479; 25 µg/$670
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
42.4 kDa
50 µg/$854
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
37.0 kDa
10 µg/$317; 50 µg/$524
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.8 kDa
10 µg/$317; 50 µg/$524
CTSE / Cathepsin E Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.78 kDa
50 µg/$698; 10 µg/$356
CTSE / Cathepsin E Protein - CTSE enzyme activity was measured using a fluorogenic peptide substrate, Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.
Select
HEK 293 Cells
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 389 amino acid recombinant protein has a predicted molecular mass of approximately 42.3 kD. The DTT-reduced protein migrates at approximately 45 kD and the non-reduced protein migrates at approximately 90 kD by SDS-PAGE. The N-terminal amino acid is G
10 µg/$350
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.78kD
10 µg/$316; 50 µg/$519; 500 µg/$1,533; 1 mg/$2,055
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
37kD
10 µg/$316; 50 µg/$519; 500 µg/$1,627; 1 mg/$2,241
CTSE / Cathepsin E Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
42.1 kDa
50 µg/$1,070
CTSE / Cathepsin E Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
37.7 kDa
100 µg/$494
Select
293T Cells
Myc-DDK (Flag)
37.7 kDa
20 µg/$110
CTSE / Cathepsin E Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
37.7 kDa
20 µg/$150
CTSE / Cathepsin E Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
37.7 kDa
100 µg/$422
Viewing 1-14 of 14 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).