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CTSE / Cathepsin E

cathepsin E

CTSE / Cathepsin E is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene.

Gene Name: cathepsin E
Family/Subfamily: Protease , Aspartic A1
Synonyms: CTSE, CATE, Cathepsin E, Ctsea, Slow-moving proteinase, CEB
Target Sequences: AJ250717 AAA52300.1 P14091

Publications (2)

1
FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer. Camolotto SA, Pattabiraman S, Mosbruger TL, Jones A, Belova VK, Orstad G, Streiff M, Salmond L, Stubben C, Kaestner KH, Snyder EL. eLife. 2018 November;7:pii e38579. [Full Text Article] [PubMed:30475207] [PMC:PMC6303105] Related Antibodies: LS-B523.
2
An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma. Rediet Zewdu , Elnaz Mirzaei Mehrabad , Kelley Ingram , Pengshu Fang , Katherine L Gillis , Soledad A Camolotto , Grace Orstad , Alex Jones , Michelle C Mendoza , Benjamin T Spike , Eric L Snyder. eLife. 2021 Apr;10:e66788. [Full Text Article] [PubMed:33821796] [PMC:PMC8102067] Related Antibodies: LS-B523.

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).