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CTSD / Cathepsin D

cathepsin D

CTSD / Cathepsin D is a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. In Chinese hamster the protein Cathepsin D is encoded by the gene H671_3g9701 (Uniprot G3I4W7).

Gene Name: cathepsin D
Family/Subfamily: Protease , Aspartic A1
Synonyms: CTSD, CPSD, CLN10, Lysosomal aspartyl peptidase, Lysosomal aspartyl protease, ProCathepsin D, CatD, Cathepsin D
Target Sequences: NM_001909 NP_001900.1 P07339

Publications (2)

1
Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aß and tau pathology. Perez SE, He B, Nadeem M, Wuu J, Ginsberg SD, Ikonomovic MD, Mufson EJ. Journal of neuropathology and experimental neurology. 2015 74:345-58. (WB; Human) [Full Text Article] [PubMed:25756588] [PMC:PMC4366294]
2
Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence. Lenain C, Gusyatiner O, Douma S, van den Broek B, Peeper DS. Carcinogenesis. 2015 November;36:1263-1274. [Full Text Article] [PubMed:26354777]

☰ Filters
Products
Proteins (20)
Over-Expression Lysate (2)
Recombinant (18)
CTSD / Cathepsin D (20)
No (20)
6His, C-terminus (4)
GST (2)
GST, N-terminus + His, C-terminus (1)
His (7)
His, N-Terminal (2)
His-GST (1)
His-SUMO (1)
Myc-DDK (Flag) (2)
Hamster-Chinese (1)
Human (12)
Mouse (3)
Rat (3)
293F Cells (1)
293T Cells (1)
E. coli (11)
HEK 293 Cells (1)
Human Cells (3)
Mammalian Cells (2)
Wheat Germ Extract (1)
Purified (3)
Low endotoxin level (5)
Select
E. coli
His
40.9 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CTSD / Cathepsin D Protein
Select
E. coli
His-SUMO
53.28 kD
1 mg/$1,679; 50 µg/$422; 100 µg/$598; 20 µg/$405
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.9kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
CTSD / Cathepsin D Protein - Eukaryotic Cathepsin D (CTSD) by SDS-PAGE
Select
293F Cells
His, N-Terminal
50kDa
10 µg/$309; 50 µg/$617; 200 µg/$1,178; 100 µg/$985; 1 mg/$2,400; 500 µg/$1,905; 5 mg/$4,305; 2 mg/$2,593
CTSD / Cathepsin D Protein
Select
E. coli
GST, N-terminus + His, C-terminus
72.4 kDa
50 µg/$419
Select
E. coli
GST
64.2 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CTSD / Cathepsin D Protein - 12.5% SDS-PAGE of human CTSD stained with Coomassie Blue
Select
Wheat Germ Extract
GST
71.06 kDa
10 µg/$479; 25 µg/$670
CTSD / Cathepsin D Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
44.4 kDa
20 µg/$150
CTSD / Cathepsin D Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
44.4 kDa
100 µg/$494
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
44 kDa
50 µg/$854; 1 mg/$5,281
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.8 kDa
10 µg/$344; 50 µg/$584
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.9 kDa
50 µg/$862
CTSD / Cathepsin D Protein
Select
E. coli
His, N-Terminal
43 kDa
10 µg/$265; 100 µg/$365; 50 µg/$315
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.8kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
CTSD / Cathepsin D Protein - Recombinant Cathepsin D By SDS-PAGE
Select
E. coli
His
16.7 kDa
10 µg/$303; 50 µg/$582; 100 µg/$930; 200 µg/$1,126; 1 mg/$2,327; 500 µg/$1,837; 5 mg/$4,061; 2 mg/$2,519
CTSD / Cathepsin D Protein - Recombinant Cathepsin D By SDS-PAGE
Select
E. coli
His
27.8 kDa
10 µg/$303; 50 µg/$582; 100 µg/$930; 200 µg/$1,126; 1 mg/$2,327; 500 µg/$1,837; 5 mg/$4,061; 2 mg/$2,519
CTSD / Cathepsin D Protein - Recombinant Cathepsin D By SDS-PAGE
Select
E. coli
His
39.4 kDa
10 µg/$306; 50 µg/$597; 100 µg/$955; 200 µg/$1,148; 1 mg/$2,361; 500 µg/$1,868; 5 mg/$4,173; 2 mg/$2,553
CTSD / Cathepsin D Protein - Recombinant Cathepsin D By SDS-PAGE
Select
E. coli
His
9.2 kDa
10 µg/$310; 50 µg/$622; 100 µg/$992; 200 µg/$1,185; 1 mg/$2,410; 500 µg/$1,915; 5 mg/$4,341; 2 mg/$2,603
CTSD / Cathepsin D Protein - Recombinant Cathepsin D By SDS-PAGE
Select
E. coli
His
13.7 kDa
10 µg/$310; 50 µg/$622; 100 µg/$992; 200 µg/$1,185; 1 mg/$2,410; 500 µg/$1,915; 5 mg/$4,341; 2 mg/$2,603
CTSD / Cathepsin D Protein - Recombinant Cathepsin D By SDS-PAGE
Select
E. coli
His-GST
63.6 kDa
10 µg/$310; 50 µg/$622; 100 µg/$992; 200 µg/$1,185; 1 mg/$2,410; 500 µg/$1,915; 5 mg/$4,341; 2 mg/$2,603
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).