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CTSC / Cathepsin C / JP

cathepsin C

CTSC / Cathepsin C / JP, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: cathepsin C
Family/Subfamily: Protease , Cysteine C1
Synonyms: CTSC, Cathepsin J, Dipeptidyl peptidase 1, Dipeptidyl peptidase I, DPP-I, Dipeptidyl transferase, Dipeptidyl-peptidase I, CPPI, DPPI, DPP1, HMS, JP, PDON1, PLS, JPD, Cathepsin C, PALS
Target Sequences: NM_001814 NP_001805.3 P53634

Publications (1)

1
Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence. Lenain C, Gusyatiner O, Douma S, van den Broek B, Peeper DS. Carcinogenesis. 2015 November;36:1263-1274. [Full Text Article] [PubMed:26354777]

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Proteins (9)
Over-Expression Lysate (4)
Recombinant (5)
CTSC / Cathepsin C / JP (9)
No (9)
GST (1)
His (3)
Myc-DDK (Flag) (5)
Human (6)
Mouse (1)
293T Cells (2)
E. coli (2)
HEK 293 Cells (3)
Human Cells (1)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (1)
CTSC / Cathepsin C / JP Protein - Recombinant Cathepsin C By SDS-PAGE
Select
E. coli
His
27.2 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
CTSC / Cathepsin C / JP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
12.8 kDa
100 µg/$494
CTSC / Cathepsin C / JP Protein - 12.5% SDS-PAGE of human CTSC stained with Coomassie Blue
Select
Wheat Germ Extract
GST
78.2 kDa
10 µg/$479; 25 µg/$670
CTSC / Cathepsin C / JP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
51.84 kDa
20 µg/$215
CTSC / Cathepsin C / JP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
12.8 kDa
20 µg/$150
CTSC / Cathepsin C / JP Protein - Purified recombinant protein CTSC was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
49.5 kDa
20 µg/$1,107
CTSC / Cathepsin C / JP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
51.84 kDa
100 µg/$710
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
51 kDa
50 µg/$854
CTSC / Cathepsin C / JP Protein - Recombinant Cathepsin C By SDS-PAGE
Select
E. coli
His
27.6 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).