CTSB / Cathepsin B

cathepsin B

Cathepsin B is a lysosomal cysteine proteinase synthesized as a zymogen of 39-47 kilodaltons (kD), which is subsequently converted into an active single- chain form of 33 kD (CB33) and, by additional processing, into the active 2-chain form containing a heavy chain of 27-29 kD (CB(27-29)) and a light chain of 4-6 kD. Cathepsin B is usually found in perinuclear lysosomes of epithelial cells of normal organs and non-malignant tumors, but is associated with the plasma membranes of many solid organ malignant tumors. Cathepsin B, a marker of the dedifferentiated chondrocyte phenotype, has been shown to contribute to cartilage destruction in osteoarthritis and pathological proteolysis in rheumatoid arthritis and cancer. Increased or altered CB expression has been documented in a variety of tumor cells. It has also been suggested that a cat B-mitochondrial apoptotic pathway plays a pivotal role in TNF-alpha-induced hepatocyte apoptosis and liver injury.

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Products

Proteins (33)

Type

Over-Expression Lysate (12)

Recombinant (21)

Target

CTSB / Cathepsin B (33)

Application

SDS-PAGE (1)

Product Group

Coronavirus Antibodies Proteins cDNAs (33)

SARS-CoV-2 Associated Proteins (33)

Publications

No (33)

Tag

6His, C-terminus (4)

GST (2)

GST, N-terminus (1)

His (7)

His,C-terminus (1)

Myc-DDK (Flag) (16)

Species

Human (21)

Mouse (4)

Rat (2)

Source

293T Cells (6)

CHO Cells (1)

E. coli (4)

HEK 293 Cells (12)

Human Cells (7)

Wheat Germ Extract (3)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (11)

Biologically Active

Biologically active (3)

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Rat CTSB / Cathepsin B Protein (Recombinant His) (aa129-333) - LS-G15108

Source:

E. coli

Tag:

His

Molecular Weight:

23.9 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human CTSB / Cathepsin B Protein (Recombinant His,C-terminus) (Arg18-Ile339) - LS-G48612

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human CTSB existing as the proform consists of 332 amino acids and has a predicted molecular mass of 37.2 kDa. rhCTSB migrates with the molecular weight of 36 and 43 kDa as the proform and mature form rspectively in SDS-PAGE under reducing conditions.

Price:

50 µg/$441

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Human CTSB / Cathepsin B Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65193

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

20 µg/$1,107

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Human CTSB / Cathepsin B Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65196

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

20 µg/$1,107

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Human CTSB / Cathepsin B Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65194

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

20 µg/$1,107

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Human CTSB / Cathepsin B Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65195

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

20 µg/$1,107

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Human CTSB / Cathepsin B Protein (Recombinant 6His, C-terminus) (Arg18-Ile339) - LS-G38918

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

36.9kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157

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Mouse CTSB / Cathepsin B Protein (Recombinant 6His, C-terminus) (His18-Phe339) - LS-G40023

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

36.4kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353

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Human CTSB / Cathepsin B Protein (Recombinant GST, N-terminus) (aa224-333) - LS-G58261

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CTSB / Cathepsin B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75047

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.82 kDa

Price:

20 µg/$150

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Human CTSB / Cathepsin B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75049

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

20 µg/$150

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Human CTSB / Cathepsin B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75048

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

20 µg/$150

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Human CTSB / Cathepsin B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75050

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

20 µg/$150

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Human CTSB / Cathepsin B Protein (Recombinant His) (Arg18-Ile339) - LS-G97361

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

37.2 kDa

Price:

50 µg/$854

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Human CTSB / Cathepsin B Protein (Recombinant His) (aa129-333) - LS-G15103

Source:

E. coli

Tag:

His

Molecular Weight:

23.7 kDa

Price:

10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796

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Mouse CTSB / Cathepsin B Protein (Recombinant His) (aa129-333) - LS-G15106

Source:

E. coli

Tag:

His

Molecular Weight:

23.7 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human CTSB / Cathepsin B Protein (Recombinant GST) (Full Length) - LS-G28099

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

64.2 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CTSB / Cathepsin B Protein (Recombinant GST) (Full Length) - LS-G28102

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

60.72 kDa

Price:

10 µg/$479; 25 µg/$670

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CTSB / Cathepsin B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G106520

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

100 µg/$494

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CTSB / Cathepsin B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G106521

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

100 µg/$494

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CTSB / Cathepsin B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G106522

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

100 µg/$494

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CTSB / Cathepsin B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102330

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

100 µg/$494

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Human CTSB / Cathepsin B Protein (Recombinant) - LS-G137736

Source:

HEK 293 Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg (determined by LAL method).

Molecular Weight:

The 332 amino acid recombinant protein has a predicted molecular mass of approximately 37 kD. The DTT-reduced and non-reduced protein migrate at approximately 45 kD by SDS-PAGE. The predicted N-terminal amino acid is Arg.

Price:

10 µg/$355; 25 µg/$497; 500 µg/$3,043

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Mouse CTSB / Cathepsin B Protein (Recombinant 6His, C-terminus) (Met1-Phe339) - LS-G140599

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

36.4 kDa

Price:

10 µg/$317; 50 µg/$524

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CTSB / Cathepsin B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G127403

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

100 µg/$494

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