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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CTR9

CTR9, Paf1/RNA polymerase II complex component

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3.

Gene Name: CTR9, Paf1/RNA polymerase II complex component
Synonyms: CTR9, p150, SH2BP1, SH2 domain-binding protein 1, KIAA0155, p150TSP, TSBP
Target Sequences: NM_014633 NP_055448.1 Q6PD62

☰ Filters
Viewing 1-12 of 12 items
CTR9 Antibody - Immunohistochemical of paraffin-embedded M. testis section using Mouse Ctr9 antibody diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.
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Rabbit Polyclonal to Mouse CTR9
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
400µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human CTR9
Human
ELISA, IF, IHC, WB
Unconjugated
100µg   $355.00
Select
Rabbit Polyclonal (IgG) to Human CTR9
Human
ELISA, IF, IHC, WB
Unconjugated
100µg   $355.00
CTR9 Antibody - Detection of Human CTR9 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-CTR9 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
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Rabbit Polyclonal (IgG) to Human CTR9
Mouse, Human
IHC, IP, WB
Unconjugated
100µl   1mg/ml   $405.00
CTR9 Antibody - Immunofluorescence staining of CTR9 in RT4 cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human CTR9 polyclonal antibody (dilution ratio 1:200) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to Nucleus.
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Rabbit Polyclonal (IgG) to Human CTR9
Human
ICC, IF
Unconjugated
50µl   $235.00; 100µl   $275.00; 200µl   $305.00
CTR9 Antibody - Detection of Human CTR9 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-CTR9 used at a dilution of 1:250.
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Rabbit Polyclonal (IgG) to Human CTR9
Mouse, Human
IHC
Unconjugated
100µl   $415.00
CTR9 Antibody - Western blot analysis of extracts of various cells.
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Rabbit Polyclonal (IgG) to Human CTR9
Mouse, Rat, Human
WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $295.00; 200µl   $385.00
CTR9 Antibody - Western blot of lysates from A431, HT-29 cell line (from left to right) with Mouse Ctr9 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 35 ug per lane.
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Rabbit Polyclonal to Human CTR9
Human
WB
Unconjugated
400µl   $325.00
CTR9 Antibody - CTR9 antibody Western Blot of Jurkat.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human CTR9
Dog, Horse, Bat, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
CTR9 Antibody - CTR9 antibody Western Blot of Jurkat.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human CTR9
Dog, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
WB
HRP Conjugated
100µl   0.65mg/ml   $385.00
CTR9 Antibody - CTR9 antibody Western Blot of Jurkat.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human CTR9
Dog, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
WB
Biotin Conjugated
100µl   1mg/ml   $385.00
CTR9 Antibody - CTR9 antibody Western Blot of Jurkat.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human CTR9
Dog, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100µl   1mg/ml   $385.00

Viewing 1-12 of 12 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).