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CTNND1 / p120 Catenin

catenin (cadherin-associated protein), delta 1

Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.

Gene Name: catenin (cadherin-associated protein), delta 1
Family/Subfamily: Catenin , not assigned-Catenin
Synonyms: CTNND1, CAS, Catenin delta-1, CTNND, KIAA0384, p120, p120(CAS), p120(CTN), p120CAS, p120CTN, p120 catenin, p120-catenin
Target Sequences: NM_001331 NP_001322.1 O60716

Publications (2)

1
P120 catenin is associated with desmogleins when desmosomes are assembled in high-Ca2+ medium but not when disassembled in low-Ca2+ medium in DJM-1 cells. Kanno M, Aoyama Y, Isa Y, Yamamoto Y, Kitajima Y. The Journal of dermatology. 2008 35:317-24. (ICC, IP) [PubMed:18578707]
2
Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion. Petrova YI, Spano MM, Gumbiner BM. Molecular biology of the cell. 2012 23:2092-108. (IF) [PubMed:22513089] [PMC:PMC3364174]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).