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CTNND1 / p120 Catenin

catenin (cadherin-associated protein), delta 1

Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.

Gene Name: catenin (cadherin-associated protein), delta 1
Family/Subfamily: Catenin , not assigned-Catenin
Synonyms: CTNND1, CAS, Catenin delta-1, CTNND, KIAA0384, p120, p120(CAS), p120(CTN), p120CAS, p120CTN, p120 catenin, p120-catenin
Target Sequences: NM_001331 NP_001322.1 O60716

Publications (2)

1
P120 catenin is associated with desmogleins when desmosomes are assembled in high-Ca2+ medium but not when disassembled in low-Ca2+ medium in DJM-1 cells. Kanno M, Aoyama Y, Isa Y, Yamamoto Y, Kitajima Y. The Journal of dermatology. 2008 35:317-24. (ICC, IP) [PubMed:18578707]
2
Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion. Petrova YI, Spano MM, Gumbiner BM. Molecular biology of the cell. 2012 23:2092-108. (IF) [PubMed:22513089] [PMC:PMC3364174]

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Antibodies (73)
Primary (73)
CTNND1 / p120 Catenin (73)
Human (71)
Mouse (30)
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rabbit (47)
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No (73)
CTNND1 / p120 Catenin Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
CTNND1 / p120 Catenin Rabbit anti-Human Polyclonal (aa75-125) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$485
CTNND1 / p120 Catenin Antibody - Immunohistochemical analysis of Catenin delta 1 (pY228) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CTNND1 / p120 Catenin Rabbit anti-Human Polyclonal (pTyr228) Antibody
Mouse, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$263; 100 µl/$315; 200 µl/$379
CTNND1 / p120 Catenin Antibody - Immunohistochemistry of paraffin-embedded Human gastric tissue.
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CTNND1 / p120 Catenin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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CTNND1 / p120 Catenin Mouse anti-Mouse Monoclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IP, WB
Unconjugated
100 µl/$860
CTNND1 / p120 Catenin Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CTNND1 / p120 Catenin Rabbit anti-Human Monoclonal (EP66) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.05 ml/$460
CTNND1 / p120 Catenin Antibody - 1:100 staining rat brain tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CTNND1 / p120 Catenin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CTNND1 / p120 Catenin Antibody - IHC of paraffin-embedded Human breast tissue using anti-CTNND1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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CTNND1 / p120 Catenin Mouse anti-Human Monoclonal (OTI3G1) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
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CTNND1 / p120 Catenin Mouse anti-Human Monoclonal (APC) Antibody
Mouse, Rat, Human
Flo, ICC, WB
APC Conjugated
100 µl/$1,027
CTNND1 / p120 Catenin Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
CTNND1 / p120 Catenin Rabbit anti-Human Polyclonal (aa891-C-term) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$485
CTNND1 / p120 Catenin Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using Catenin-d1 (Phospho-Tyr228) antibody.
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CTNND1 / p120 Catenin Rabbit anti-Human Polyclonal (pTyr228) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
CTNND1 / p120 Catenin Antibody - Immunohistochemistry image of paraffin-embedded human colon cancer at a dilution of 1:100
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CTNND1 / p120 Catenin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
CTNND1 / p120 Catenin Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using Catenin-delta1 (Phospho-Tyr228) Antibody. The picture on the right is blocked with the phospho peptide.
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CTNND1 / p120 Catenin Rabbit anti-Human Polyclonal (pTyr228) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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CTNND1 / p120 Catenin Rabbit anti-Human Polyclonal (aa387-416) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
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CTNND1 / p120 Catenin Rabbit anti-Human Polyclonal (aa387-416) (Biotin) Antibody
Human
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
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CTNND1 / p120 Catenin Rabbit anti-Human Polyclonal (aa387-416) (FITC) Antibody
Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
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CTNND1 / p120 Catenin Rabbit anti-Human Polyclonal (aa387-416) (APC) Antibody
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
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CTNND1 / p120 Catenin Rabbit anti-Human Polyclonal (aa387-416) (PE) Antibody
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
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CTNND1 / p120 Catenin Rabbit anti-Human Polyclonal (aa387-416) (Azide-free) (HRP) Antibody
Human
ELISA, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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CTNND1 / p120 Catenin Mouse anti-Mouse Monoclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, IF, IP, WB
Unconjugated
100 µl/$842
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CTNND1 / p120 Catenin Mouse anti-Mouse Monoclonal (C-Terminus) (15D2) Antibody
Chicken, Dog, Rat, Human
ELISA, IF, IP, WB
Unconjugated
100 µl/$842
CTNND1 / p120 Catenin Antibody - Western blot of Phospho-p120 (Y228) antibody
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CTNND1 / p120 Catenin Rabbit anti-Human Polyclonal (180-260 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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CTNND1 / p120 Catenin Mouse anti-Human Monoclonal Antibody
Human
Flo, ICC, IP, WB
Unconjugated
100 µg/$786
CTNND1 / p120 Catenin Antibody - IHC of paraffin-embedded Human breast tissue using anti-CTNND1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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CTNND1 / p120 Catenin Mouse anti-Human Monoclonal (OTI2E8) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
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CTNND1 / p120 Catenin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IP, WB
Unconjugated
100 µg/$331
CTNND1 / p120 Catenin Antibody - Anti-CTNND1 / p120CTN antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:15.
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CTNND1 / p120 Catenin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µl/$505
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).