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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
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CTLA4 / CD152
cytotoxic T-lymphocyte-associated protein 4
CTLA4 / CD152 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Phenotyping of Leukocytes and Leukocyte-Derived Extracellular Vesicles. Pugholm LH, Bæk R, Søndergaard EK, Revenfeld AL, Jørgensen MM, Varming K. Journal of immunology research. 2016 2016:6391264. (Flo; Human)[Full Text Article]
[PubMed:27195303]
[PMC:PMC4852366]
Related Antibodies: LS-C134750.
2
Progression of benign prostatic hyperplasia is associated with pro-inflammatory mediators and chronic activation of prostate-infiltrating lymphocytes. Norström MM, Rådestad E, Sundberg B, Mattsson J, Henningsohn L, Levitsky V, Uhlin M. Oncotarget. 2016 7:23581-93. (Flo, ELISA; Human)[Full Text Article]
[PubMed:26993768]
[PMC:PMC5029649]
3
The Spectrum of Mild to Severe Psoriasis Vulgaris Is Defined by a Common Activation of IL-17 Pathway Genes, but with Key Differences in Immune Regulatory Genes. Kim J, Bissonnette R, Lee J, Correa da Rosa J, Suárez-Fariñas M, Lowes MA, Krueger JG. The Journal of investigative dermatology. 2016 November;136:2173-2182. (Human)[Full Text Article]
[PubMed:27185339]
Related Antibodies: LS-C35849.
4
Individualization of Hematopoietic Stem Cell Transplantation Using Alpha/Beta T-Cell Depletion. Emelie Rådestad, Mikael Sundin, Johan Törlén, Sarah Thunberg, Björn Önfelt, Per Ljungman, Emma Watz, Jonas Mattsson, Michael Uhlin. Frontiers in immunology. 2019 February;10:189. [Full Text Article]
[PubMed:30804948]
[PMC:PMC6378311]
5
Immunological function of Langerhans cells in HIV infection. Takamitsu Matsuzawa, Youichi Ogawa, Kohji Moriishi, Shinji Shimada, Tatsuyoshi Kawamura. Journal of dermatological science. 2017 Aug;87:159-167. [Full Text Article]
[PubMed:28433429]
6
Transfer learning between preclinical models and human tumors identifies a conserved NK cell activation signature in anti-CTLA-4 responsive tumors. Emily F Davis-Marcisak # , Allison A Fitzgerald #, Michael D Kessler, Ludmila Danilova, Elizabeth M Jaffee, Neeha Zaidi, Louis M Weiner, Elana J Fertig. Genome medicine. 2021 Aug;13:129. [Full Text Article]
[PubMed:34376232]
[PMC:PMC8356429]
Related Antibodies: LS-C193047.
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).