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CTH / Cystathionase
cystathionase (cystathionine gamma-lyase)
Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.
| Gene Name: | cystathionase (cystathionine gamma-lyase) |
| Synonyms: | CTH, Cysteine-protein sulfhydrase, Cysteine desulfhydrase, Cystathionine gamma-lyase, Homoserine dehydratase, Gamma-cystathionase, Homoserine deaminase |
| Target Sequences: | NM_001902 NP_001893.2 P32929 |
Publications (1)
1
Clear cell and endometrioid carcinomas: are their differences attributable to distinct cells of origin?. Dawn R Cochrane, Basile Tessier-Cloutier, Katherine M Lawrence, Tayyebeh Nazeran, Anthony N Karnezis, Clara Salamanca, Angela S Cheng, Jessica N McAlpine, Lien N Hoang, C Blake Gilks, David G Huntsman. The Journal of pathology. 2017 September;243:26-36. [Full Text Article]
[PubMed:28678427]
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CTH / Cystathionase Mouse anti-Human Monoclonal (1E12) Antibody
Dog, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
CTH / Cystathionase Rabbit anti-Human Polyclonal (aa38-87) Antibody
Human
WB
Unconjugated
100 µl/$424
![CTH / Cystathionase Antibody - Immunoperoxidase of monoclonal antibody to CTH on formalin-fixed paraffin-embedded human pancreas. [antibody concentration 3 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/cth-cystathionase-antibody-clone-s51-ls-c133145/50566_5026522.jpg)
CTH / Cystathionase Mouse anti-Human Monoclonal (S51) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$423
CTH / Cystathionase Mouse anti-Human Monoclonal (4E1-1B7) Antibody
Rat, Human
ELISA, WB
Unconjugated
100 µg/$423
CTH / Cystathionase Mouse anti-Human Monoclonal (2D6) Antibody
Dog, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$460
CTH / Cystathionase Rabbit anti-Human Polyclonal (aa316-331) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CTH / Cystathionase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
CTH / Cystathionase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
CTH / Cystathionase Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, IP, WB
Unconjugated
100 µg/$351
CTH / Cystathionase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IHC, IP, WB
Unconjugated
100 µg/$331
CTH / Cystathionase Mouse anti-Human Monoclonal (Carrier-free) (1.00E+12) Antibody
Dog, Human, Monkey
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CTH / Cystathionase Mouse anti-Human Monoclonal (Carrier-free) (2D6) Antibody
Dog, Human, Monkey
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CTH / Cystathionase Rabbit anti-Human Polyclonal (aa281-330) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
CTH / Cystathionase Rabbit anti-Human Polyclonal (aa281-330) (HRP) Antibody
Human, Chimpanzee, Orangutan, Gibbon
IHC, IHC-P, WB
HRP Conjugated
100 µl/$442
CTH / Cystathionase Rabbit anti-Human Polyclonal (aa281-330) (Biotin) Antibody
Human, Chimpanzee, Orangutan, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
CTH / Cystathionase Rabbit anti-Human Polyclonal (aa281-330) (FITC) Antibody
Human, Chimpanzee, Orangutan, Gibbon
IHC, IHC-P, WB
FITC Conjugated
100 µl/$442
CTH / Cystathionase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CTH / Cystathionase Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
CTH / Cystathionase Rabbit anti-Human Polyclonal Antibody
Human
IP, WB
Unconjugated
100 µl/$749
CTH / Cystathionase Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CTH / Cystathionase Rabbit anti-Mouse Polyclonal (aa14-224) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
CTH / Cystathionase Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
CTH / Cystathionase Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
CTH / Cystathionase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$575
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