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CTDSP2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
| Gene Name: | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 |
| Synonyms: | CTDSP2, NLI-interacting factor 2, OS4, PSR2, Small CTD phosphatase 2, NIF2, Protein OS-4 |
| Target Sequences: | NM_005730 NP_005721.3 O14595 |
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