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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CSNK2A1

casein kinase 2, alpha 1 polypeptide

Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry.

Gene Name: casein kinase 2, alpha 1 polypeptide
Family/Subfamily: Protein Kinase , Casein kinase II
Synonyms: CSNK2A1, Casein kinase II alpha, Casein kinase II subunit alpha, Ck2 alpha, CK2 catalytic subunit alpha, CKII, CKIIalpha, CK2A1, CKII alpha, Protein kinase CK2, Casein kinase 2 alpha, CK II alpha
Target Sequences: NM_001895 NP_001886.1 P68400

Filtered by: None
Target
CSNK2A1 (70)
Reactivity
Human (68)
Mouse (46)
Rat (36)
Bat (5)
Bovine (7)
Chicken (11)
Chimpanzee (3)
Dog (5)
Drosophila (4)
Frog (6)
Gibbon (3)
Guinea pig (4)
Hamster (2)
Horse (5)
Monkey (5)
Orangutan (3)
Pig (5)
Rabbit (11)
Xenopus (5)
Zebrafish (4)
Application
IHC (30)
IHC-P (6)
WB (64)
DB (6)
ELISA (31)
ICC (8)
IF (3)
IP (13)
Peptide-ELISA (3)
Host
rabbit (59)
mouse (11)
Isotype
IgG (52)
IgG1 (7)
IgG2a,k (2)
IgG2b,k (1)
Clonality
monoclonal mc (11)
polyclonal pc (59)
Clone
3D9 (1)
Format
AP Conjugated (4)
APC Conjugated (4)
Azide-free (1)
Biotin Conjugated (6)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (4)
Unconjugated (40)
Epitope
aa240-269 (8)
aa1-391 (4)
aa218-267 (4)
190-270 aa (2)
aa300-350 (2)
Internal (1)
Thr251 (1)
aa1-50 (1)
aa162-195 (1)
aa202-251 (1)
aa221-270 (1)
aa250-284 (1)
aa28-50 (1)
aa319-324 (1)
aa350-C-term (1)
aa7-22 (1)
pTyr255 (1)
Publications
No (70)
Showing 1-25 of 70 results

IHC-plus™ CSNK2A1 Antibody LS-B7845
Mouse Monoclonal (IgG2b,k) to Human CSNK2A1
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-CSNK2A1 / CKII antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Anti-CSNK2A1 / CKII antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.

CSNK2A1 Antibody LS-C121138
Mouse Monoclonal (IgG1) to Human CSNK2A1
Mouse, Rat, Human
ICC, IP, WB
Unconjugated
100µg  $605.00

CSNK2A1 Antibody (HRP) LS-C544024
Mouse Monoclonal (IgG1) to Human CSNK2A1
Mouse, Rat, Human
DB, ICC, IHC, IP, WB
HRP Conjugated
100µl  $800.00

CSNK2A1 Antibody (Biotin) LS-C523898
Mouse Monoclonal (IgG1) to Human CSNK2A1
Mouse, Rat, Human
DB, ICC, IHC, IP, WB
Biotin Conjugated
100µl  $800.00

CSNK2A1 Antibody (FITC) LS-C533923
Mouse Monoclonal (IgG1) to Human CSNK2A1
Mouse, Rat, Human
DB, ICC, IHC, IP, WB
FITC Conjugated
100µl  $800.00

CSNK2A1 Antibody (APC) LS-C515512
Mouse Monoclonal (IgG1) to Human CSNK2A1
Mouse, Rat, Human
DB, ICC, IHC, IP, WB
APC Conjugated
100µl  $800.00

CSNK2A1 Antibody (PE) LS-C652111
Mouse Monoclonal (IgG1) to Human CSNK2A1
Mouse, Rat, Human
DB, ICC, IHC, IP, WB
PE Conjugated
100µl  $800.00

CSNK2A1 Antibody (AP) LS-C505943
Mouse Monoclonal (IgG1) to Human CSNK2A1
Mouse, Rat, Human
DB, ICC, IHC, IP, WB
AP Conjugated
100µl  $800.00

CSNK2A1 Antibody (Internal) LS-C358961
Rabbit Polyclonal to Human CSNK2A1
Rabbit, Mouse, Bovine, Rat, Human
IHC, IHC-P, WB
Unconjugated
30µl 1mg/ml  $205.00; 100µl 1mg/ml  $245.00; 200µl 1mg/ml  $305.00
Immunohistochemical analysis of CK2 alpha staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Western blot analysis of CK2 alpha expression in HEK293T (A); Raw264.7 (B); PC12 (C) whole cell lysates.

CSNK2A1 Antibody (aa300-350) LS-C287120
Rabbit Polyclonal (IgG) to Human CSNK2A1
Human
IHC, WB
Unconjugated
100µl 1mg/ml  $395.00
Detection of Human CKII Alpha by Immunohistochemistry. Sample: FFPE section of human non-small cell lung cancer. Antibody: Affinity purified rabbit anti-CKII Alpha used at a dilution of 1:1000 (1 ug/ml).
Detection of mouse CKII Alpha by immunohistochemistry. Sample: FFPE section of mouse teratoma. Antibody: Affinity purified rabbit anti-CKII Alpha used at a dilution of 1:1,000 (1µg/ml). Detection: DAB

IHC-plus™ CSNK2A1 Antibody LS-B7844
Mouse Monoclonal (IgG2a,k) to Human CSNK2A1
Mouse, Rat, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µl  $425.00
Anti-CSNK2A1 / CKII antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Western blot Image

CSNK2A1 Antibody (aa350-C-term) LS-C287123
Rabbit Polyclonal (IgG) to Human CSNK2A1
Mouse, Human
IHC, IP, WB
Unconjugated
100µl 1mg/ml  $395.00
Detection of Human CKII Alpha by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-CKII Alpha used at a dilution of 1:5000 (0.2 ug/ml).
Detection of Human and Mouse CKII alpha by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-CKII alpha antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.

CSNK2A1 Antibody LS-C664829
Rabbit Polyclonal (IgG) to Human CSNK2A1
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100µg  $335.00

CSNK2A1 Antibody LS-C806740
Rabbit Polyclonal (IgG) to Human CSNK2A1
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00

CSNK2A1 Antibody (clone 3D9) LS-C196985
Mouse Monoclonal [clone 3D9] (IgG2a,k) to Human CSNK2A1
Human
ELISA, IF, WB
Unconjugated
100µg  $365.00
Immunofluorescence of monoclonal antibody to CSNK2A1 on HeLa cell. [antibody concentration 10 ug/ml]
CSNK2A1 monoclonal antibody (M01), clone 3D9 Western Blot analysis of CSNK2A1 expression in HeLa NE.

CSNK2A1 Antibody LS-C400660
Rabbit Polyclonal (IgG) to Human CSNK2A1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl 0.3mg/ml  $205.00; 60µl 0.3mg/ml  $235.00; 120µl 0.3mg/ml  $295.00; 200µl 0.3mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human brain using CSNK2A1 Polyclonal Antibody at dilution of 1:13.
Immunohistochemistry of paraffin-embedded Human cervical cancer using CSNK2A1 Polyclonal Antibody at dilution of 1:13.

CSNK2A1 Antibody (aa250-284) LS-C344239
Rabbit Polyclonal to Human CSNK2A1
Human
IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Immunohistochemical of paraffin-embedded R.kidney section using CSNK2A1 Antibody. Antibody was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
Immunohistochemical of paraffin-embedded H. brain section using CSNK2A1 Antibody. Antibody was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.

CSNK2A1 Antibody (aa319-324) LS-C21280
Mouse Monoclonal (IgG) to Human CSNK2A1
Mouse, Bovine, Rat, Hamster, Human
ELISA, ICC, WB
Unconjugated
50µg  $475.00

CSNK2A1 Antibody (aa240-269) LS-C327022
Rabbit Polyclonal (IgG) to Human CSNK2A1
Mouse, Human
ELISA, IHC, WB
Unconjugated
200µl  $590.00

CSNK2A1 Antibody (aa240-269, APC) LS-C275948
Rabbit Polyclonal (IgG) to Human CSNK2A1
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200µl  $740.00

CSNK2A1 Antibody (190-270 aa) LS-C380984
Rabbit Polyclonal (IgG) to Human CSNK2A1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of Phospho-Casein Kinase IIalpha (Y255) antibody

CSNK2A1 Antibody (190-270 aa) LS-C382441
Rabbit Polyclonal (IgG) to Human CSNK2A1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of Casein Kinase IIalpha antibody

CSNK2A1 Antibody LS-C403919
Rabbit Polyclonal (IgG) to Human CSNK2A1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl 0.5mg/ml  $205.00; 60µl 0.5mg/ml  $235.00; 120µl 0.5mg/ml  $295.00; 200µl 0.5mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human liver cancer using CSNK2A1 Polyclonal Antibody at dilution of 1:30.
Western blot analysis of K562 and 293T cell, Jurkat cell and mouse brain tissue, using CSNK2A1 Polyclonal Antibody at dilution of 1:300.

CSNK2A1 Antibody LS-C485682
Rabbit Polyclonal to Mouse CSNK2A1
Mouse
ELISA, IP, WB
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00

CSNK2A1 Antibody (aa240-269) LS-C101283
Rabbit Polyclonal to Human CSNK2A1
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma
The anti-CSNK2A1 antibody is used in Western blot to detect CSNK2A1 in mouse brain tissue lysate.
Showing 1-25 of 70 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).