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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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CSNK2A1

casein kinase 2, alpha 1 polypeptide

Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry.

Gene Name: casein kinase 2, alpha 1 polypeptide
Family/Subfamily: Protein Kinase , Casein kinase II
Synonyms: CSNK2A1, Casein kinase II alpha, Casein kinase II subunit alpha, Ck2 alpha, CK2 catalytic subunit alpha, CKII, CKIIalpha, CK2A1, CKII alpha, Protein kinase CK2, Casein kinase 2 alpha, CK II alpha
Target Sequences: NM_001895 NP_001886.1 P68400


CSNK2A1 Antibody - Anti-CSNK2A1 / CKII antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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Mouse Monoclonal (IgG2b,k) to Human CSNK2A1
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
CSNK2A1 Antibody - Anti-CSNK2A1 / CKII antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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Mouse Monoclonal (IgG2a,k) to Human CSNK2A1
Mouse, Rat, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µl   $425.00
Select
Mouse Monoclonal (IgG1) to Human CSNK2A1
Mouse, Rat, Human
ICC, IP, WB
Unconjugated
100µg   $605.00
Select
Mouse Monoclonal (IgG1) to Human CSNK2A1
Mouse, Rat, Human
DB, ICC, IHC, IP, WB
HRP Conjugated
100µl   $800.00
Select
Mouse Monoclonal (IgG1) to Human CSNK2A1
Mouse, Rat, Human
DB, ICC, IHC, IP, WB
Biotin Conjugated
100µl   $800.00
Select
Mouse Monoclonal (IgG1) to Human CSNK2A1
Mouse, Rat, Human
DB, ICC, IHC, IP, WB
FITC Conjugated
100µl   $800.00
Select
Mouse Monoclonal (IgG1) to Human CSNK2A1
Mouse, Rat, Human
DB, ICC, IHC, IP, WB
AP Conjugated
100µl   $800.00
Select
Mouse Monoclonal (IgG1) to Human CSNK2A1
Mouse, Rat, Human
DB, ICC, IHC, IP, WB
APC Conjugated
100µl   $800.00
Select
Mouse Monoclonal (IgG1) to Human CSNK2A1
Mouse, Rat, Human
DB, ICC, IHC, IP, WB
PE Conjugated
100µl   $800.00
CSNK2A1 Antibody - Immunohistochemical analysis of CK2 alpha staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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Rabbit Polyclonal to Human CSNK2A1
Rabbit, Mouse, Bovine, Rat, Human
IHC, IHC-P, WB
Unconjugated
30µl   1mg/ml   $205.00; 100µl   1mg/ml   $245.00; 200µl   1mg/ml   $305.00
CSNK2A1 Antibody - Detection of Human CKII Alpha by Immunohistochemistry. Sample: FFPE section of human non-small cell lung cancer. Antibody: Affinity purified rabbit anti-CKII Alpha used at a dilution of 1:1000 (1 ug/ml).
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Rabbit Polyclonal (IgG) to Human CSNK2A1
Human
IHC, WB
Unconjugated
100µl   1mg/ml   $405.00
CSNK2A1 Antibody - Detection of Human CKII Alpha by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-CKII Alpha used at a dilution of 1:5000 (0.2 ug/ml).
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Rabbit Polyclonal (IgG) to Human CSNK2A1
Mouse, Human
IHC, IP, WB
Unconjugated
100µl   1mg/ml   $405.00
CSNK2A1 Antibody - 1:100 staining mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Rabbit Polyclonal (IgG) to Human CSNK2A1
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Human CSNK2A1
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100µg   $355.00
CSNK2A1 Antibody - Immunofluorescence of monoclonal antibody to CSNK2A1 on HeLa cell. [antibody concentration 10 ug/ml]
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Mouse Monoclonal [clone 3D9] (IgG2a,k) to Human CSNK2A1
Human
ELISA, IF, WB
Unconjugated
100µg   $365.00
CSNK2A1 Antibody - Immunohistochemical of paraffin-embedded R.kidney section using CSNK2A1 Antibody. Antibody was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
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Rabbit Polyclonal to Human CSNK2A1
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Mouse Monoclonal (IgG) to Human CSNK2A1
Mouse, Bovine, Rat, Hamster, Human
ELISA, ICC, WB
Unconjugated
50µg   $680.00
Select
Rabbit Polyclonal (IgG) to Human CSNK2A1
Mouse, Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human CSNK2A1
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human CSNK2A1
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human CSNK2A1
Mouse, Human
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
CSNK2A1 Antibody - Western blot of Phospho-Casein Kinase IIalpha (Y255) antibody
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Rabbit Polyclonal (IgG) to Human CSNK2A1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
CSNK2A1 Antibody - Western blot of Casein Kinase IIalpha antibody
Select
Rabbit Polyclonal (IgG) to Human CSNK2A1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
CSNK2A1 Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer using CSNK2A1 Polyclonal Antibody at dilution of 1:30.
Select
Rabbit Polyclonal (IgG) to Human CSNK2A1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl   0.3mg/ml   $205.00; 60µl   0.3mg/ml   $235.00; 120µl   0.3mg/ml   $295.00; 200µl   0.3mg/ml   $395.00
Select
Rabbit Polyclonal to Mouse CSNK2A1
Mouse
ELISA, IP, WB
Unconjugated
50µl   $235.00; 100µl   $275.00; 200µl   $305.00
Viewing 1-25 of 69 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).