CSNK1G2 / CKI-Gamma 2

casein kinase 1, gamma 2

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

CSNK1G2 / CKI-Gamma 2 (8)

Publications

No (8)

Tag

6His, N-terminus (2)

GST (1)

GST, N-terminus (1)

GST, N-terminus + His, C-terminus (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (8)

Source

293T Cells (1)

Baculovirus (1)

E. coli (3)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (3)

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Human CSNK1G2 / CKI-Gamma 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99408

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.3 kDa

Price:

100 µg/$494

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Human CSNK1G2 / CKI-Gamma 2 Protein (Recombinant 6His, N-terminus) (Met18-Lys415) - LS-G139431

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

47.6 kDa

Price:

10 µg/$368; 50 µg/$504

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Human CSNK1G2 / CKI-Gamma 2 Protein (Recombinant GST, N-terminus + His, C-terminus) - LS-G144911

Source:

E. coli

Tag:

GST, N-terminus + His, C-terminus

Molecular Weight:

75.3 kDa

Price:

50 µg/$419

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Human CSNK1G2 / CKI-Gamma 2 Protein (Recombinant GST) (Full Length) - LS-G28067

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

71.39 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CSNK1G2 / CKI-Gamma 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75022

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.3 kDa

Price:

20 µg/$150

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Human CSNK1G2 / CKI-Gamma 2 Protein (Recombinant GST, N-terminus) (aa315-415) - LS-G58245

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CSNK1G2 / CKI-Gamma 2 Protein (Recombinant His) (Met18-Lys415) - LS-G97352

Source:

Baculovirus

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

47.8 kDa

Price:

50 µg/$707

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Human CSNK1G2 / CKI-Gamma 2 Protein (Recombinant 6His, N-terminus) (Met18-Lys415) - LS-G39759

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

47.6kD

Price:

10 µg/$281; 50 µg/$420; 500 µg/$1,585; 1 mg/$2,157

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