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Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
|Gene Name:||casein kinase 1, gamma 2|
|Family/Subfamily:||Protein Kinase , Casein kinase I|
|Synonyms:||CSNK1G2, Casein kinase 1, gamma 2, Casein kinase I gamma 2, CKI Gamma 2, CKI-gamma 2, CK1 gamma 2, CK1g2, Casein Kinase 1 gamma 2|
|Target Sequences:||NM_001319 NP_001310.3 P78368|
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