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CSNK1G2 / CKI-Gamma 2

casein kinase 1, gamma 2

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.

Gene Name: casein kinase 1, gamma 2
Family/Subfamily: Protein Kinase , Casein kinase I
Synonyms: CSNK1G2, Casein kinase 1, gamma 2, Casein kinase I gamma 2, CKI Gamma 2, CKI-gamma 2, CK1 gamma 2, CK1g2, Casein Kinase 1 gamma 2
Target Sequences: NM_001319 NP_001310.3 P78368

☰ Filters
Products
Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
CSNK1G2 / CKI-Gamma 2 (8)
No (8)
6His, N-terminus (2)
GST (1)
GST, N-terminus (1)
GST, N-terminus + His, C-terminus (1)
His (1)
Myc-DDK (Flag) (2)
Human (8)
293T Cells (1)
Baculovirus (1)
E. coli (3)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (3)
CSNK1G2 / CKI-Gamma 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
47.3 kDa
100 µg/$494
CSNK1G2 / CKI-Gamma 2 Protein
Select
E. coli
GST, N-terminus + His, C-terminus
75.3 kDa
50 µg/$419
CSNK1G2 / CKI-Gamma 2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CSNK1G2 / CKI-Gamma 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
47.3 kDa
20 µg/$150
CSNK1G2 / CKI-Gamma 2 Protein - 12.5% SDS-PAGE of human CSNK1G2 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
71.39 kDa
10 µg/$479; 25 µg/$670
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
47.6 kDa
10 µg/$368; 50 µg/$504
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
47.6kD
10 µg/$281; 50 µg/$420; 500 µg/$1,585; 1 mg/$2,157
Select
Baculovirus
His
Less than 1.0 EU/µg protein (determined by LAL method).
47.8 kDa
50 µg/$707
Viewing 1-8 of 8 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).