CSNK1D

casein kinase 1, delta

Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.

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Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

CSNK1D (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His-T7 (1)

Myc-DDK (Flag) (4)

Species

Human (6)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human CSNK1D Protein (Recombinant His) - LS-G2905

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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CSNK1D Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107119

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.7 kDa

Price:

100 µg/$494

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Human CSNK1D Protein (Recombinant His-T7) (aa1-415) - LS-G25263

Source:

E. coli

Tag:

His-T7

Molecular Weight:

51.0 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human CSNK1D Protein (Recombinant GST) (Full Length) - LS-G28064

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

73.7 kDa

Price:

2 µg/$439

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Human CSNK1D Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75018

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.1 kDa

Price:

20 µg/$150

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Human CSNK1D Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75019

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.7 kDa

Price:

20 µg/$150

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Human CSNK1D Protein (Recombinant GST, N-terminus) (aa301-415) - LS-G58241

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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CSNK1D Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99589

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.1 kDa

Price:

100 µg/$494

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