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Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis.
Gene Name: | casein kinase 1, alpha 1 |
Family/Subfamily: | Protein Kinase , Casein kinase I |
Synonyms: | CSNK1A1, CK1 alpha, CK1a, CK1alpha, Clock regulator kinase, CK1, Casein kinase 1 alpha, CKIa, CKIalpha, Down-regulated in lung cancer, HLCDGP1, PRO2975, Casein kinase 1, alpha 1, Casein kinase I alpha, Casein kinase I isoform alpha, CKI-alpha |
Target Sequences: | NM_001892 NP_001883.4 P48729 |
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