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CSF2 / GM-CSF

colony stimulating factor 2 (granulocyte-macrophage)

CSF2 / GM-CSF is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13.

Gene Name: colony stimulating factor 2 (granulocyte-macrophage)
Synonyms: CSF2, Colony-stimulating factor, CSF, GM-CSF, Molgramostin, GMCSF
Target Sequences: NM_000758 NP_000749.2 P04141

Publications (2)

1
Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human Pancreatic Cancer. Takeuchi S, Baghdadi M, Tsuchikawa T, Wada H, Nakamura T, Abe H, Nakanishi S, Usui Y, Higuchi K, Takahashi M, Inoko K, Sato S, Takano H, Shichinohe T, Seino K, Hirano S. Cancer research. 2015 75:2629-40. (IHC; Human) [Full Text Article] [PubMed:25952647] Related Antibodies: LS-C104671.
2
Expression of granulocyte macrophage-colony stimulating factor and its receptor in the synovium of osteoarthritis patients is negatively correlated with pain. Eefje M van Helvoort, Niels Eijkelkamp, Floris P J G Lafeber, Simon C Mastbergen. Rheumatology (Oxford, England). 2020 November;59:3452-3457. [Full Text Article] [PubMed:32365364] Related Antibodies: LS-C41956.

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).