CSE1L

CSE1 chromosome segregation 1-like (yeast)

Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

CSE1L (6)

Publications

No (6)

Tag

6His-SUMO, N-terminus (1)

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human CSE1L Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65233

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

110.2 kDa

Price:

20 µg/$1,107

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Human CSE1L Protein (Recombinant GST, N-terminus) (aa872-971) - LS-G58234

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CSE1L Protein (Recombinant 6His-SUMO, N-terminus) (aa1-200) - LS-G57502

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

100 µg/$1,128; 20 µg/$721

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Human CSE1L Protein (Recombinant GST) (Full Length) - LS-G28052

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

49.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CSE1L Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75137

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

110.2 kDa

Price:

20 µg/$215

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CSE1L Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118663

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

110.2 kDa

Price:

100 µg/$710

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