CSA / ERCC8

excision repair cross-complementing rodent repair deficiency, complementation group 8

Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.

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Products

Proteins (7)

Type

Over-Expression Lysate (4)

Recombinant (3)

Target

CSA / ERCC8 (7)

Publications

No (7)

Tag

GST (2)

His, N-Terminal (1)

Myc-DDK (Flag) (4)

Species

Human (5)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human CSA / ERCC8 Protein (Recombinant His, N-Terminal) - LS-G143898

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

23.2 kDa

Price:

50 µg/$419

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Human CSA / ERCC8 Protein (Recombinant GST) (Full Length) - LS-G27932

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

48.29 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CSA / ERCC8 Protein (Recombinant GST) (Full Length) - LS-G27933

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

69.19 kDa

Price:

10 µg/$479; 25 µg/$670

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CSA / ERCC8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123408

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.9 kDa

Price:

100 µg/$494

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Human CSA / ERCC8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75238

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.9 kDa

Price:

20 µg/$150

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Human CSA / ERCC8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75241

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.18 kDa

Price:

20 µg/$150

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CSA / ERCC8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121961

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.18 kDa

Price:

100 µg/$494

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