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CSA / ERCC8
excision repair cross-complementing rodent repair deficiency, complementation group 8
Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.
| Gene Name: | excision repair cross-complementing rodent repair deficiency, complementation group 8 |
| Synonyms: | ERCC8, CKN1, UVSS2, CSA |
| Target Sequences: | NM_000082 NP_000073.1 Q13216 |
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