CRYAB / Alpha B Crystallin

crystallin, alpha B

Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants.

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Products

Proteins (13)

Type

Over-Expression Lysate (2)

Recombinant (9)

Target

CRYAB / Alpha B Crystallin (13)

Publications

No (13)

Tag

6His, C-terminus (2)

6His, N-terminus (1)

GST (1)

His-SUMO (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (10)

Mouse (2)

Source

293T Cells (1)

E. coli (9)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (2)

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Human CRYAB / Alpha B Crystallin Protein (Recombinant His-SUMO) (Full Length) - LS-G20630

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

36.1 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Mouse CRYAB / Alpha B Crystallin Protein - LS-G134040

Source:

E. coli

Tag:

None

Molecular Weight:

20 kDa

Price:

20 µg/$412; 1000 µg/$3,417

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Human CRYAB / Alpha B Crystallin Protein - LS-G134039

Source:

E. coli

Tag:

None

Molecular Weight:

20.2 kDa

Price:

20 µg/$329; 100 µg/$412; 1000 µg/$1,515

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CRYAB / Alpha B Crystallin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118335

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20 kDa

Price:

100 µg/$494

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Human CRYAB / Alpha B Crystallin Protein (Recombinant His-T7) (aa1-175) - LS-G25175

Source:

E. coli

Tag:

His-T7

Molecular Weight:

24.0 kDa

Price:

10 µg/$279; 50 µg/$430; 100 µg/$687; 200 µg/$857; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142

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Human CRYAB / Alpha B Crystallin Protein (Recombinant GST) (Full Length) - LS-G28038

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

44.99 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CRYAB / Alpha B Crystallin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74410

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20 kDa

Price:

20 µg/$150

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Human CRYAB / Alpha B Crystallin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64892

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20 kDa

Price:

20 µg/$1,107

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Human CRYAB / Alpha B Crystallin Protein (Recombinant 6His, N-terminus) (Asp2-Lys175) - LS-G26505

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

22 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

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Human CRYAB / Alpha B Crystallin Protein (Recombinant 6His, C-terminus) (Met1-Lys175) - LS-G38655

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

21.22kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Mouse CRYAB / Alpha B Crystallin Protein (Recombinant) - LS-G3384

Source:

E. coli

Tag:

None

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human CRYAB / Alpha B Crystallin Protein (Recombinant) - LS-G3382

Source:

E. coli

Tag:

None

Price:

100 µg/$329; 20 µg/$279; 10 µg/$254; 50 µg/$320; 250 µg/$367; 500 µg/$479

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Human CRYAB / Alpha B Crystallin Protein (Recombinant 6His, C-terminus) (Met1-Lys175) - LS-G139732

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

21.2 kDa

Price:

10 µg/$288; 50 µg/$436

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