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CRY1
cryptochrome circadian clock 1
CRY1 / Cryptochrome circadian clock 1 encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness.
| Gene Name: | cryptochrome circadian clock 1 |
| Synonyms: | CRY1, Chryptochrome 1, Cryptochrome-1, Photolyase homolog 1, PHLL1 |
| Target Sequences: | NM_004075 NP_004066.1 Q16526 |
Publications (1)
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