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CRTC3
CREB regulated transcription coactivator 3
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
| Gene Name: | CREB regulated transcription coactivator 3 |
| Synonyms: | CRTC3, TORC-3, TORC3, Transducer of CREB protein 3 |
| Target Sequences: | NM_022769 NP_073606.3 Q6UUV7 |
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