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CRLF2 / TSLPR

cytokine receptor-like factor 2

CRLF2 / TSLPR is a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.

Gene Name: cytokine receptor-like factor 2
Synonyms: CRLF2, IL-XR, ILXR, p2RY8/CRLF2 fusion, TSLP receptor, TSLPR, CRL2, CRLF2Y, Cytokine receptor-like 2
Target Sequences: AK026800 BAB15557.1 Q9HC73

Publications (1)

1
Anti-CRLF2 Antibody-Armored Biodegradable Nanoparticles for Childhood B-ALL. Raghunathan R, Mahesula S, Kancharla K, Janardhanan P, Jadhav YL, Nadeau R, Villa GP, Cook RL, Witt CM, Gelfond JA, Forsthuber TG, Haskins WE. Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems. 2013 30:355-364. (WB; Human) [Full Text Article] [PubMed:23976822] [PMC:PMC3746557] Related Antibodies: LS-C40791.

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CRLF2 / TSLPR (7)
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CRLF2 / TSLPR ELISA Kit
Select
Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$923
CRLF2 / TSLPR ELISA Kit
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Custom
96-Well Strip Plate
Mouse
1 Plate/$783
CRLF2 / TSLPR ELISA Kit
Select
Custom
96-Well Strip Plate
Human
1 Plate/$783
CRLF2 / TSLPR ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
1 Plate/$783
CRLF2 / TSLPR ELISA Kit
Select
Sandwich
Mouse
125 - 8000 pg/ml
Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Serum
1 Plate/$1,150
CRLF2 / TSLPR ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$717
CRLF2 / TSLPR ELISA Kit
Select
Sandwich
96-Well Microplate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$1,150
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).