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CRFR1 / CRHR1
corticotropin releasing hormone receptor 1
G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
| Gene Name: | corticotropin releasing hormone receptor 1 |
| Family/Subfamily: | GPCR , Corticotropin releasing factor |
| Synonyms: | CRHR1, CRF-R-1, CRFR, CRHR1f, Crf receptor 1, CRH-R1, CRF-R, CRF1, CRFR-1, Crf receptor type 1, Crf receptor type 1, Crf type 1, CRF-R1, Crf1 receptor, CRFR1, CRH-R-1, CRH-R1h, CRHR, CRHR1L |
| Target Sequences: | NM_004382 P34998 P34998 |
Publications (2)
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