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CREBL1 / ATF6B
activating transcription factor 6 beta
CREBL1 / ATF6B is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | activating transcription factor 6 beta |
| Synonyms: | ATF6B, ATF6-beta, Creb-related protein, CREBL1, G13, CREB-RP, Protein G13 |
| Target Sequences: | NM_004381 NP_004372.3 Q99941 |
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